Abstract
The biocatalytic preparation of trans-hex-2-enal from trans-hex-2-enol using a novel aryl alcohol oxidase from Pleurotus eryngii (PeAAOx) is reported. As O 2-dependent enzyme PeAAOx-dependent reactions are generally plagued by the poor solubility of O 2 in aqueous media and mass transfer limitations resulting in poor reaction rates. These limitations were efficiently overcome by conducting the reaction in a flow-reactor setup reaching unpreceded catalytic activities for the enzyme in terms of turnover frequency (up to 38 s -1) and turnover numbers (more than 300000) pointing towards preparative usefulness of the proposed reaction scheme.
Original language | English |
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Pages (from-to) | 697-703 |
Number of pages | 7 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 14 |
DOIs | |
Publication status | Published - 26 Mar 2018 |
Bibliographical note
This article is part of the Thematic Series "Integrated multistep flow synthesis". Guest Editor: V. HesselKeywords
- alcohol oxidase
- alcohol oxidation
- aldehyde
- flow chemistry
- Alcohol oxidase
- Flow chemistry
- Alcohol oxidation
- Aldehyde