Binary self-assembly of oligoadenylic acid and oligo(p-phenylenevinylene) having a thymidylic acid at each end

Rika Iwaura, F. J.M. Hoeben, A. P.H.J. Schenning, Mitsutoshi Masuda, E. W. Meijer, Toshimi Shimizu

Research output: Contribution to conferencePaperAcademic

Abstract

We have reported the self-assembly of nucleotide-attached bolaamphiphiles in aqueous solutions1). On the other hand, π -conjugated oligomers are one of the attentions in electro-optical chemistry2). In this research, we have synthesized an oligo(p-phenylenevinylene) having a thymidylic acid at each end, and examined its self-assembly and binary self-assembly with complementary oligoadenylic acid (dA20). The self-assembled structures were examined by AFM, FE-SEM, UV and CD spectroscopy. We can find non-helical columnar structures by AFM and FE-SEM observations from the self-assembly of T-OPV-T with diameters of 3.8 nm, which well fits with the molecular length of T-OPV-T. Helical columnar structures are observed from the binary self-assembly of T-OPV-T and dA20, with 5.8nm diameters and 35nm helical pitches. The UV and CD measurements reveal that the formation of complementary A-T base pairs and π- π stacking interaction between the OPV moieties in the binary-self-assembly.

Original languageEnglish
Pages5073-5074
Number of pages2
Publication statusPublished - 1 Dec 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 20 Sep 200522 Sep 2005

Conference

Conference54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period20/09/0522/09/05

Keywords

  • DNA
  • Oligo(p-phenylenevinylene)
  • Self-Assembly
  • Template
  • Thymidylic Acid

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    Iwaura, R., Hoeben, F. J. M., Schenning, A. P. H. J., Masuda, M., Meijer, E. W., & Shimizu, T. (2005). Binary self-assembly of oligoadenylic acid and oligo(p-phenylenevinylene) having a thymidylic acid at each end. 5073-5074. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.