Beat-to-beat variation in pulse wave velocity during breathing maneuvers

N.R. Gaddum, T. Schaeffter, M. Bührer, M.C.M. Rutten, L. Smith, P.J. Chowienczyk, P.B.J. Beerbaum

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Purpose Thoracic pulse wave velocity (PWV) variation due to modulated trans-mural pressure (TMP) may indicate mechanical properties of the aorta. Our aim was to measure beat-to-beat thoracic PWV and TMP to observe its normal variation during respiratory maneuvers. Methods We validated PWV measurements from a real-time velocity projection MRI scan in a pulsatile phantom. A volunteer study showed inter-scan repeatability of steady-state PWV, and observed PWV variation when performing Mueller and Valsalva maneuvers. Synchronized to the real-time projection velocity data, TMP was measured using a mouth piece and pressure sensor arrangement monitoring the intra-thoracic pressure and a single arterial pressure measurement. Results In the phantom, beat-to-beat PWV derived from real-time projection (5.33 ± 0.32 m s -1) agreed well with experimentally derived PWV using ultrasound probes (5.72 ± 0.50 m s-1). The within-subject PWV variation between scans was 0.28 m s-1. Volunteers' PWVs increased during Mueller maneuver (TMP increase of 14.67 ± 10.69 mmHg) by 32% (P <0.001), and during Valsalva maneuver (TMP decrease of TMP = 17.01 ± 12.91 mmHg), PWV response were inconsistent with an average increase of 14% (P <0.05). Conclusion Gating TMP to beat-to-beat PWV allows insight into how aortic stiffness varies with strain. However, quantifying nonlinear arterial stiffness requires real-time arterial pressure measurement.

Original languageEnglish
Pages (from-to)202-210
Number of pages9
JournalMagnetic Resonance in Medicine
Volume72
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Pulse Wave Analysis
Respiration
Pressure
Valsalva Maneuver
Vascular Stiffness
Thorax
Volunteers
Arterial Pressure
Mouth
Aorta
Magnetic Resonance Imaging

Keywords

  • magnetic resonance
  • Mueller
  • pulse wave velocity
  • real time phase contrast
  • respiratory maneuver
  • Valsalva

Cite this

Gaddum, N. R., Schaeffter, T., Bührer, M., Rutten, M. C. M., Smith, L., Chowienczyk, P. J., & Beerbaum, P. B. J. (2014). Beat-to-beat variation in pulse wave velocity during breathing maneuvers. Magnetic Resonance in Medicine, 72(1), 202-210. https://doi.org/10.1002/mrm.24890
Gaddum, N.R. ; Schaeffter, T. ; Bührer, M. ; Rutten, M.C.M. ; Smith, L. ; Chowienczyk, P.J. ; Beerbaum, P.B.J. / Beat-to-beat variation in pulse wave velocity during breathing maneuvers. In: Magnetic Resonance in Medicine. 2014 ; Vol. 72, No. 1. pp. 202-210.
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abstract = "Purpose Thoracic pulse wave velocity (PWV) variation due to modulated trans-mural pressure (TMP) may indicate mechanical properties of the aorta. Our aim was to measure beat-to-beat thoracic PWV and TMP to observe its normal variation during respiratory maneuvers. Methods We validated PWV measurements from a real-time velocity projection MRI scan in a pulsatile phantom. A volunteer study showed inter-scan repeatability of steady-state PWV, and observed PWV variation when performing Mueller and Valsalva maneuvers. Synchronized to the real-time projection velocity data, TMP was measured using a mouth piece and pressure sensor arrangement monitoring the intra-thoracic pressure and a single arterial pressure measurement. Results In the phantom, beat-to-beat PWV derived from real-time projection (5.33 ± 0.32 m s -1) agreed well with experimentally derived PWV using ultrasound probes (5.72 ± 0.50 m s-1). The within-subject PWV variation between scans was 0.28 m s-1. Volunteers' PWVs increased during Mueller maneuver (TMP increase of 14.67 ± 10.69 mmHg) by 32{\%} (P <0.001), and during Valsalva maneuver (TMP decrease of TMP = 17.01 ± 12.91 mmHg), PWV response were inconsistent with an average increase of 14{\%} (P <0.05). Conclusion Gating TMP to beat-to-beat PWV allows insight into how aortic stiffness varies with strain. However, quantifying nonlinear arterial stiffness requires real-time arterial pressure measurement.",
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Gaddum, NR, Schaeffter, T, Bührer, M, Rutten, MCM, Smith, L, Chowienczyk, PJ & Beerbaum, PBJ 2014, 'Beat-to-beat variation in pulse wave velocity during breathing maneuvers', Magnetic Resonance in Medicine, vol. 72, no. 1, pp. 202-210. https://doi.org/10.1002/mrm.24890

Beat-to-beat variation in pulse wave velocity during breathing maneuvers. / Gaddum, N.R.; Schaeffter, T.; Bührer, M.; Rutten, M.C.M. ; Smith, L.; Chowienczyk, P.J.; Beerbaum, P.B.J.

In: Magnetic Resonance in Medicine, Vol. 72, No. 1, 2014, p. 202-210.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Beat-to-beat variation in pulse wave velocity during breathing maneuvers

AU - Gaddum, N.R.

AU - Schaeffter, T.

AU - Bührer, M.

AU - Rutten, M.C.M.

AU - Smith, L.

AU - Chowienczyk, P.J.

AU - Beerbaum, P.B.J.

PY - 2014

Y1 - 2014

N2 - Purpose Thoracic pulse wave velocity (PWV) variation due to modulated trans-mural pressure (TMP) may indicate mechanical properties of the aorta. Our aim was to measure beat-to-beat thoracic PWV and TMP to observe its normal variation during respiratory maneuvers. Methods We validated PWV measurements from a real-time velocity projection MRI scan in a pulsatile phantom. A volunteer study showed inter-scan repeatability of steady-state PWV, and observed PWV variation when performing Mueller and Valsalva maneuvers. Synchronized to the real-time projection velocity data, TMP was measured using a mouth piece and pressure sensor arrangement monitoring the intra-thoracic pressure and a single arterial pressure measurement. Results In the phantom, beat-to-beat PWV derived from real-time projection (5.33 ± 0.32 m s -1) agreed well with experimentally derived PWV using ultrasound probes (5.72 ± 0.50 m s-1). The within-subject PWV variation between scans was 0.28 m s-1. Volunteers' PWVs increased during Mueller maneuver (TMP increase of 14.67 ± 10.69 mmHg) by 32% (P <0.001), and during Valsalva maneuver (TMP decrease of TMP = 17.01 ± 12.91 mmHg), PWV response were inconsistent with an average increase of 14% (P <0.05). Conclusion Gating TMP to beat-to-beat PWV allows insight into how aortic stiffness varies with strain. However, quantifying nonlinear arterial stiffness requires real-time arterial pressure measurement.

AB - Purpose Thoracic pulse wave velocity (PWV) variation due to modulated trans-mural pressure (TMP) may indicate mechanical properties of the aorta. Our aim was to measure beat-to-beat thoracic PWV and TMP to observe its normal variation during respiratory maneuvers. Methods We validated PWV measurements from a real-time velocity projection MRI scan in a pulsatile phantom. A volunteer study showed inter-scan repeatability of steady-state PWV, and observed PWV variation when performing Mueller and Valsalva maneuvers. Synchronized to the real-time projection velocity data, TMP was measured using a mouth piece and pressure sensor arrangement monitoring the intra-thoracic pressure and a single arterial pressure measurement. Results In the phantom, beat-to-beat PWV derived from real-time projection (5.33 ± 0.32 m s -1) agreed well with experimentally derived PWV using ultrasound probes (5.72 ± 0.50 m s-1). The within-subject PWV variation between scans was 0.28 m s-1. Volunteers' PWVs increased during Mueller maneuver (TMP increase of 14.67 ± 10.69 mmHg) by 32% (P <0.001), and during Valsalva maneuver (TMP decrease of TMP = 17.01 ± 12.91 mmHg), PWV response were inconsistent with an average increase of 14% (P <0.05). Conclusion Gating TMP to beat-to-beat PWV allows insight into how aortic stiffness varies with strain. However, quantifying nonlinear arterial stiffness requires real-time arterial pressure measurement.

KW - magnetic resonance

KW - Mueller

KW - pulse wave velocity

KW - real time phase contrast

KW - respiratory maneuver

KW - Valsalva

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DO - 10.1002/mrm.24890

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