Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

M.F. Debets; Sander S. Van Berkel; Sanne Schoffelen; F.P.J.T. Rutjes; J.C.M. van Hest; F.L. van Delft

doi:10.1039/b917797c

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

M.F. Debets, Sander S. Van Berkel, Sanne Schoffelen, F.P.J.T. Rutjes, J.C.M. van Hest, F.L. van Delft

Research output: Contribution to journal › Article › Academic › peer-review

452 Citations (Scopus)

Abstract

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

Original language	English
Pages (from-to)	97-99
Number of pages	3
Journal	Chemical Communications, ChemComm
Volume	46
Issue number	1
DOIs	https://doi.org/10.1039/b917797c
Publication status	Published - 2010
Externally published	Yes

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abstract = "A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.",

author = "M.F. Debets and {Van Berkel}, {Sander S.} and Sanne Schoffelen and F.P.J.T. Rutjes and {van Hest}, J.C.M. and {van Delft}, F.L.",

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AU - Debets, M.F.

AU - Van Berkel, Sander S.

AU - Schoffelen, Sanne

AU - Rutjes, F.P.J.T.

AU - van Hest, J.C.M.

AU - van Delft, F.L.

PY - 2010

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AB - A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

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SN - 1359-7345

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JO - Chemical Communications, ChemComm

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ER -

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

Abstract

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