Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

M.F. Debets, Sander S. Van Berkel, Sanne Schoffelen, F.P.J.T. Rutjes, J.C.M. van Hest, F.L. van Delft

Research output: Contribution to journalArticleAcademicpeer-review

386 Citations (Scopus)

Abstract

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalChemical Communications
Volume46
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

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