Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

M.F. Debets, Sander S. Van Berkel, Sanne Schoffelen, F.P.J.T. Rutjes, J.C.M. van Hest, F.L. van Delft

Research output: Contribution to journalArticleAcademicpeer-review

356 Citations (Scopus)

Abstract

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalChemical Communications
Volume46
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

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Azides
Cycloaddition
Copper
Enzymes
Kinetics

Cite this

Debets, M.F. ; Van Berkel, Sander S. ; Schoffelen, Sanne ; Rutjes, F.P.J.T. ; van Hest, J.C.M. ; van Delft, F.L. / Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. In: Chemical Communications. 2010 ; Vol. 46, No. 1. pp. 97-99.
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Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. / Debets, M.F.; Van Berkel, Sander S.; Schoffelen, Sanne; Rutjes, F.P.J.T.; van Hest, J.C.M.; van Delft, F.L.

In: Chemical Communications, Vol. 46, No. 1, 2010, p. 97-99.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Rutjes, F.P.J.T.

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AU - van Delft, F.L.

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