Autonomic nervous system functioning associated with psychogenic nonepileptic seizures: analysis of heart rate variability

S.J.M. van der Kruijs, K.E.J. Vonck, G.R. Langereis, L.M.G. Feijs, N.M.G Bodde, R.H.C. Lazeron, E.C.B. Carrette, P.A.J.M. Boon, W.H. Backes, J.F.A. Jansen, A.P. Aldenkamp, P.J.M. Cluitmans

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Abstract

Objective: Psychogenic nonepileptic seizures (PNESs) resemble epileptic seizures but originate from psychogenic rather than organic causes. Patients with PNESs are often unable or unwilling to reflect on underlying emotions. To gain more insight into the internal states of patients during PNES episodes, this study explored the time course of heart rate variability (HRV) measures, which provide information about autonomic nervous system functioning and arousal. Methods: Heart rate variability measures were extracted from double-lead electrocardiography data collected during 1-7. days of video-electroencephalography monitoring of 20 patients with PNESs, in whom a total number of 118 PNESs was recorded. Heart rate (HR) and HRV measures in time and frequency domains (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive differences (RMSSD), high-frequency (HF) power, low-frequency (LF) power, and very low-frequency (VLF) power) were averaged over consecutive five-minute intervals. Additionally, quantitative analyses of Poincaré plot parameters (SD1, SD2, and SD1/SD2 ratio) were performed. Results: In the five-minute interval before PNES, HR significantly (p <0.05) increased (d = 2.5), whereas SDANN (d = - 0.03) and VLF power (d = - 0.05) significantly decreased. During PNES, significant increases in HF power (d = 0.0006), SD1 (d = 0.031), and SD2 (d = 0.016) were observed. In the five-minute interval immediately following PNES, SDANN (d = 0.046) and VLF power (d = 0.073) significantly increased, and HR (d = - 5.1) and SD1/SD2 ratio (d = - 0.14) decreased, compared to the interval preceding PNES. Conclusion: The results suggest that PNES episodes are preceded by increased sympathetic functioning, which is followed by an increase in parasympathetic functioning during and after PNES. Future research needs to identify the exact nature of the increased arousal that precedes PNES.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalEpilepsy and Behavior
Volume54
DOIs
Publication statusPublished - 23 Nov 2015

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Autonomic Nervous System
Seizures
Heart Rate
Arousal
Physiologic Monitoring
Power (Psychology)
Electroencephalography
Epilepsy
Electrocardiography
Emotions

Keywords

  • Autonomic nervous system
  • Conversion disorder
  • Heart rate variability
  • Psychogenic nonepileptic seizures
  • Vagal tone

Cite this

@article{e23707a90f1049b1b62d16d47c757a5e,
title = "Autonomic nervous system functioning associated with psychogenic nonepileptic seizures: analysis of heart rate variability",
abstract = "Objective: Psychogenic nonepileptic seizures (PNESs) resemble epileptic seizures but originate from psychogenic rather than organic causes. Patients with PNESs are often unable or unwilling to reflect on underlying emotions. To gain more insight into the internal states of patients during PNES episodes, this study explored the time course of heart rate variability (HRV) measures, which provide information about autonomic nervous system functioning and arousal. Methods: Heart rate variability measures were extracted from double-lead electrocardiography data collected during 1-7. days of video-electroencephalography monitoring of 20 patients with PNESs, in whom a total number of 118 PNESs was recorded. Heart rate (HR) and HRV measures in time and frequency domains (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive differences (RMSSD), high-frequency (HF) power, low-frequency (LF) power, and very low-frequency (VLF) power) were averaged over consecutive five-minute intervals. Additionally, quantitative analyses of Poincar{\'e} plot parameters (SD1, SD2, and SD1/SD2 ratio) were performed. Results: In the five-minute interval before PNES, HR significantly (p <0.05) increased (d = 2.5), whereas SDANN (d = - 0.03) and VLF power (d = - 0.05) significantly decreased. During PNES, significant increases in HF power (d = 0.0006), SD1 (d = 0.031), and SD2 (d = 0.016) were observed. In the five-minute interval immediately following PNES, SDANN (d = 0.046) and VLF power (d = 0.073) significantly increased, and HR (d = - 5.1) and SD1/SD2 ratio (d = - 0.14) decreased, compared to the interval preceding PNES. Conclusion: The results suggest that PNES episodes are preceded by increased sympathetic functioning, which is followed by an increase in parasympathetic functioning during and after PNES. Future research needs to identify the exact nature of the increased arousal that precedes PNES.",
keywords = "Autonomic nervous system, Conversion disorder, Heart rate variability, Psychogenic nonepileptic seizures, Vagal tone",
author = "{van der Kruijs}, S.J.M. and K.E.J. Vonck and G.R. Langereis and L.M.G. Feijs and N.M.G Bodde and R.H.C. Lazeron and E.C.B. Carrette and P.A.J.M. Boon and W.H. Backes and J.F.A. Jansen and A.P. Aldenkamp and P.J.M. Cluitmans",
year = "2015",
month = "11",
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doi = "10.1016/j.yebeh.2015.10.014",
language = "English",
volume = "54",
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Autonomic nervous system functioning associated with psychogenic nonepileptic seizures: analysis of heart rate variability. / van der Kruijs, S.J.M.; Vonck, K.E.J.; Langereis, G.R.; Feijs, L.M.G.; Bodde, N.M.G; Lazeron, R.H.C.; Carrette, E.C.B.; Boon, P.A.J.M.; Backes, W.H.; Jansen, J.F.A.; Aldenkamp, A.P.; Cluitmans, P.J.M.

In: Epilepsy and Behavior, Vol. 54, 23.11.2015, p. 14-19.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Autonomic nervous system functioning associated with psychogenic nonepileptic seizures: analysis of heart rate variability

AU - van der Kruijs, S.J.M.

AU - Vonck, K.E.J.

AU - Langereis, G.R.

AU - Feijs, L.M.G.

AU - Bodde, N.M.G

AU - Lazeron, R.H.C.

AU - Carrette, E.C.B.

AU - Boon, P.A.J.M.

AU - Backes, W.H.

AU - Jansen, J.F.A.

AU - Aldenkamp, A.P.

AU - Cluitmans, P.J.M.

PY - 2015/11/23

Y1 - 2015/11/23

N2 - Objective: Psychogenic nonepileptic seizures (PNESs) resemble epileptic seizures but originate from psychogenic rather than organic causes. Patients with PNESs are often unable or unwilling to reflect on underlying emotions. To gain more insight into the internal states of patients during PNES episodes, this study explored the time course of heart rate variability (HRV) measures, which provide information about autonomic nervous system functioning and arousal. Methods: Heart rate variability measures were extracted from double-lead electrocardiography data collected during 1-7. days of video-electroencephalography monitoring of 20 patients with PNESs, in whom a total number of 118 PNESs was recorded. Heart rate (HR) and HRV measures in time and frequency domains (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive differences (RMSSD), high-frequency (HF) power, low-frequency (LF) power, and very low-frequency (VLF) power) were averaged over consecutive five-minute intervals. Additionally, quantitative analyses of Poincaré plot parameters (SD1, SD2, and SD1/SD2 ratio) were performed. Results: In the five-minute interval before PNES, HR significantly (p <0.05) increased (d = 2.5), whereas SDANN (d = - 0.03) and VLF power (d = - 0.05) significantly decreased. During PNES, significant increases in HF power (d = 0.0006), SD1 (d = 0.031), and SD2 (d = 0.016) were observed. In the five-minute interval immediately following PNES, SDANN (d = 0.046) and VLF power (d = 0.073) significantly increased, and HR (d = - 5.1) and SD1/SD2 ratio (d = - 0.14) decreased, compared to the interval preceding PNES. Conclusion: The results suggest that PNES episodes are preceded by increased sympathetic functioning, which is followed by an increase in parasympathetic functioning during and after PNES. Future research needs to identify the exact nature of the increased arousal that precedes PNES.

AB - Objective: Psychogenic nonepileptic seizures (PNESs) resemble epileptic seizures but originate from psychogenic rather than organic causes. Patients with PNESs are often unable or unwilling to reflect on underlying emotions. To gain more insight into the internal states of patients during PNES episodes, this study explored the time course of heart rate variability (HRV) measures, which provide information about autonomic nervous system functioning and arousal. Methods: Heart rate variability measures were extracted from double-lead electrocardiography data collected during 1-7. days of video-electroencephalography monitoring of 20 patients with PNESs, in whom a total number of 118 PNESs was recorded. Heart rate (HR) and HRV measures in time and frequency domains (standard deviation of average beat-to-beat intervals (SDANN), root mean square of successive differences (RMSSD), high-frequency (HF) power, low-frequency (LF) power, and very low-frequency (VLF) power) were averaged over consecutive five-minute intervals. Additionally, quantitative analyses of Poincaré plot parameters (SD1, SD2, and SD1/SD2 ratio) were performed. Results: In the five-minute interval before PNES, HR significantly (p <0.05) increased (d = 2.5), whereas SDANN (d = - 0.03) and VLF power (d = - 0.05) significantly decreased. During PNES, significant increases in HF power (d = 0.0006), SD1 (d = 0.031), and SD2 (d = 0.016) were observed. In the five-minute interval immediately following PNES, SDANN (d = 0.046) and VLF power (d = 0.073) significantly increased, and HR (d = - 5.1) and SD1/SD2 ratio (d = - 0.14) decreased, compared to the interval preceding PNES. Conclusion: The results suggest that PNES episodes are preceded by increased sympathetic functioning, which is followed by an increase in parasympathetic functioning during and after PNES. Future research needs to identify the exact nature of the increased arousal that precedes PNES.

KW - Autonomic nervous system

KW - Conversion disorder

KW - Heart rate variability

KW - Psychogenic nonepileptic seizures

KW - Vagal tone

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DO - 10.1016/j.yebeh.2015.10.014

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VL - 54

SP - 14

EP - 19

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

ER -