Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

Adriana L. Smit, Jasper V. Been, Luc J.I. Zimmermann, Rene F. Kornelisse, Peter Andriessen, Sizzle F. Vanterpool, Martijn P.H. Bischoff, Robert J. Stokroos, Ronald R. de Krijger, Bernd Kremer, Boris W. Kramer

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.

Original languageEnglish
Pages (from-to)1864-1869
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number15
Publication statusPublished - 13 Oct 2015
Externally publishedYes


  • Adult
  • Chorioamnionitis/epidemiology
  • Cohort Studies
  • Evoked Potentials, Auditory, Brain Stem/physiology
  • Female
  • Fetal Membranes, Premature Rupture/epidemiology
  • HELLP Syndrome/epidemiology
  • Hearing Disorders/diagnosis
  • Hearing Tests/methods
  • Humans
  • Infant, Newborn
  • Infant, Premature/physiology
  • Infant, Premature, Diseases/diagnosis
  • Male
  • Neonatal Screening/methods
  • Netherlands/epidemiology
  • Pregnancy
  • Young Adult


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