Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

Adriana L. Smit; Jasper V. Been; Luc J.I. Zimmermann; Rene F. Kornelisse; Peter Andriessen; Sizzle F. Vanterpool; Martijn P.H. Bischoff; Robert J. Stokroos; Ronald R. de Krijger; Bernd Kremer; Boris W. Kramer

doi:10.3109/14767058.2014.971747

Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

Adriana L. Smit, Jasper V. Been, Luc J.I. Zimmermann, Rene F. Kornelisse, Peter Andriessen, Sizzle F. Vanterpool, Martijn P.H. Bischoff, Robert J. Stokroos, Ronald R. de Krijger, Bernd Kremer, Boris W. Kramer

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.

Original language	English
Pages (from-to)	1864-1869
Number of pages	6
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	28
Issue number	15
DOIs	https://doi.org/10.3109/14767058.2014.971747
Publication status	Published - 13 Oct 2015
Externally published	Yes

Funding

The study in Rotterdam was part of a research project on chorioamnionitis and neonatal outcome that was approved by the Medical Ethics Committee for Research on Human Subjects of the Erasmus University MC [14]. Written parental consent was obtained. For the Veldhoven cohort a waiver for ethical assessment and parental consent was provided by the local Medical Ethical Committee of the Máxima Medical Centre according to Dutch law, considering the retrospective and anonymized use of routinely collected medical data [16].

Keywords

Adult
Chorioamnionitis/epidemiology
Cohort Studies
Evoked Potentials, Auditory, Brain Stem/physiology
Female
Fetal Membranes, Premature Rupture/epidemiology
HELLP Syndrome/epidemiology
Hearing Disorders/diagnosis
Hearing Tests/methods
Humans
Infant, Newborn
Infant, Premature/physiology
Infant, Premature, Diseases/diagnosis
Male
Neonatal Screening/methods
Netherlands/epidemiology
Pregnancy
Young Adult

Access to Document

10.3109/14767058.2014.971747

Cite this

Smit, A. L., Been, J. V., Zimmermann, L. J. I., Kornelisse, R. F., Andriessen, P., Vanterpool, S. F., Bischoff, M. P. H., Stokroos, R. J., de Krijger, R. R., Kremer, B., & Kramer, B. W. (2015). Automated auditory brainstem response in preterm newborns with histological chorioamnionitis. Journal of Maternal-Fetal and Neonatal Medicine, 28(15), 1864-1869. https://doi.org/10.3109/14767058.2014.971747

@article{93682efa5a064d4385311aad8873dfe9,

title = "Automated auditory brainstem response in preterm newborns with histological chorioamnionitis",

abstract = "Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.",

keywords = "Adult, Chorioamnionitis/epidemiology, Cohort Studies, Evoked Potentials, Auditory, Brain Stem/physiology, Female, Fetal Membranes, Premature Rupture/epidemiology, HELLP Syndrome/epidemiology, Hearing Disorders/diagnosis, Hearing Tests/methods, Humans, Infant, Newborn, Infant, Premature/physiology, Infant, Premature, Diseases/diagnosis, Male, Neonatal Screening/methods, Netherlands/epidemiology, Pregnancy, Young Adult",

author = "Smit, {Adriana L.} and Been, {Jasper V.} and Zimmermann, {Luc J.I.} and Kornelisse, {Rene F.} and Peter Andriessen and Vanterpool, {Sizzle F.} and Bischoff, {Martijn P.H.} and Stokroos, {Robert J.} and {de Krijger}, {Ronald R.} and Bernd Kremer and Kramer, {Boris W.}",

year = "2015",

month = oct,

day = "13",

doi = "10.3109/14767058.2014.971747",

language = "English",

volume = "28",

pages = "1864--1869",

journal = "Journal of Maternal-Fetal and Neonatal Medicine",

issn = "1476-7058",

publisher = "Informa Healthcare",

number = "15",

}

Smit, AL, Been, JV, Zimmermann, LJI, Kornelisse, RF, Andriessen, P, Vanterpool, SF, Bischoff, MPH, Stokroos, RJ, de Krijger, RR, Kremer, B & Kramer, BW 2015, 'Automated auditory brainstem response in preterm newborns with histological chorioamnionitis', Journal of Maternal-Fetal and Neonatal Medicine, vol. 28, no. 15, pp. 1864-1869. https://doi.org/10.3109/14767058.2014.971747

TY - JOUR

T1 - Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

AU - Smit, Adriana L.

AU - Been, Jasper V.

AU - Zimmermann, Luc J.I.

AU - Kornelisse, Rene F.

AU - Andriessen, Peter

AU - Vanterpool, Sizzle F.

AU - Bischoff, Martijn P.H.

AU - Stokroos, Robert J.

AU - de Krijger, Ronald R.

AU - Kremer, Bernd

AU - Kramer, Boris W.

PY - 2015/10/13

Y1 - 2015/10/13

N2 - Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.

AB - Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods: Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.

KW - Adult

KW - Chorioamnionitis/epidemiology

KW - Cohort Studies

KW - Evoked Potentials, Auditory, Brain Stem/physiology

KW - Female

KW - Fetal Membranes, Premature Rupture/epidemiology

KW - HELLP Syndrome/epidemiology

KW - Hearing Disorders/diagnosis

KW - Hearing Tests/methods

KW - Humans

KW - Infant, Newborn

KW - Infant, Premature/physiology

KW - Infant, Premature, Diseases/diagnosis

KW - Male

KW - Neonatal Screening/methods

KW - Netherlands/epidemiology

KW - Pregnancy

KW - Young Adult

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U2 - 10.3109/14767058.2014.971747

DO - 10.3109/14767058.2014.971747

M3 - Article

C2 - 25294170

SN - 1476-7058

VL - 28

SP - 1864

EP - 1869

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

IS - 15

ER -

Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

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Perinatal Medicine

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Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

Abstract

Funding

Keywords

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Research areas

Perinatal Medicine

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