Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

Antoni Llopis-Lorente, Beatriz De Luis, Alba García-Fernández, Paula Díez, Alfredo Sánchez, M. Dolores Marcos, Reynaldo Villalonga, Ramón Martínez-Máñez, Félix Sancenón

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetylthiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.

Original languageEnglish
Pages (from-to)6734-6739
Number of pages6
JournalJournal of Materials Chemistry B
Volume5
Issue number33
DOIs
Publication statusPublished - 7 Sep 2017
Externally publishedYes

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