TY - JOUR
T1 - Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit
AU - Llopis-Lorente, Antoni
AU - De Luis, Beatriz
AU - García-Fernández, Alba
AU - Díez, Paula
AU - Sánchez, Alfredo
AU - Dolores Marcos, M.
AU - Villalonga, Reynaldo
AU - Martínez-Máñez, Ramón
AU - Sancenón, Félix
PY - 2017/9/7
Y1 - 2017/9/7
N2 - We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetylthiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.
AB - We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetylthiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.
UR - http://www.scopus.com/inward/record.url?scp=85028330991&partnerID=8YFLogxK
U2 - 10.1039/c7tb02045g
DO - 10.1039/c7tb02045g
M3 - Article
AN - SCOPUS:85028330991
SN - 2050-750X
VL - 5
SP - 6734
EP - 6739
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 33
ER -
