@inproceedings{ea24dfb529374243af9b384ab13a78cb,
title = "Atrial anatomy influences onset and termination of atrial fibrillation: A computer model study",
abstract = "Vulnerability to atrial fibrillation (AF) is increased in acutelydilated atria and is related to stretch-activated channels (SACs). To investigatethe role of atrial anatomy in AF, we apply a computer model ofhuman atrial electromechanics that includes SACs and contraction of thesarcomeres. Trabecular bundle structures are modeled by varying atrialwall thickness in a triangular mesh representing the human atria. Vulnerabilityto AF is investigated by application of overall stretch, whilestimulating near the pulmonary veins. Due to contraction of some areas,stretch increases in other areas, leading to a variation in effectiverefractory period (ERP). Onset and perpetuation of AF in our model isexplained by an increased dispersion in ERP, conduction slowing, andlocal conduction block. Atrial contraction attributes to the terminationof AF through mechanoelectric feedback. We conclude that onset andtermination of AF episodes under stretch are related to atrial structureand mechanoelectric feedback.",
author = "N.H.L. Kuijpers and {Eikelder, ten}, H.M.M. and S. Verheule",
year = "2009",
doi = "10.1007/978-3-642-01932-6_31",
language = "English",
isbn = "978-3-642-01931-9",
series = "Lecture Notes in Computer Science",
publisher = "Springer",
pages = "285--294",
editor = "N. Ayache and H. Delingette and M. Sermesant",
booktitle = "Functional imaging and modeling of the heart : proceedings of the 5th international conference, (FIMH 2009) Nice, France, June 3-5, 2009",
note = "5th International Conference on Functional Imaging and Modeling of the Heart (FIMH 2009), June 3-5, 2009, Nice, France, FIMH 2009 ; Conference date: 03-06-2009 Through 05-06-2009",
}