Abstract
The immune system's role in atherosclerosis has long been an important research topic and is increasingly investigated for therapeutic and diagnostic purposes. Therefore, noninvasive imaging of hematopoietic organs and immune cells will undoubtedly improve atherosclerosis phenotyping and serve as a monitoring method for immunotherapeutic treatments. Among the available imaging techniques, positron emission tomography's unique features make it an ideal tool to quantitatively image the immune response in the context of atherosclerosis and afford reliable readouts to guide medical interventions in cardiovascular disease. Here, we summarize the state of the art in the field of atherosclerosis positron emission tomography immunoimaging and provide an outlook on current and future applications.
| Original language | English |
|---|---|
| Pages (from-to) | 865-873 |
| Number of pages | 9 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 40 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Apr 2020 |
Funding
This work was supported by the National Institutes of Health grants R01HL071021, R01HL128056, R01HL144072, R01HL135878, R01HL143814, and P01 HL131478 (Z.A. Fayad); R01 HL125703 and R01 HL118440 (W.J.M. Mulder); the American Heart Association 16SDG31390007 (C. Pérez-Medina); and the Netherlands Organization for Scientific Research NWO Vidi (W.J.M. Mulder).
| Funders | Funder number |
|---|---|
| National Institutes of Health | R01HL143814, R01HL128056, P01 HL131478, R01HL135878 |
| National Heart, Lung, and Blood Institute | R01HL144072, R01HL118440, R01HL071021, R01HL125703 |
| American Heart Association | 16SDG31390007 |
| Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
Keywords
- Atherosclerosis
- Cardiovascular diseases
- Immune cells
- Immune system
- Positron emission tomography
