Assessment of endoleak significance after endovascular repair of abdominal aortic aneurysms : a lumped parameter model

The outcome of endovascular repair of abdominal aortic aneurysms (AAAs) is greatly compromised by the possible occurrence of endoleak. Previously, the causes and effects of endoleak on a patient-specific basis have mainly been investigated in experimental studies. In order to both reconcile and physically substantiate the various experimental findings, a computational model of an incompletely excluded AAA is developed. After experimental validation, the model is applied to study the effects on the intrasac pressure of the degree of endoleak, the degree of stent-graft compliance, and the resistance of a possible outflow tract formed by a branching vessel. It is concluded that the presence of endoleak leads to elevated intrasac pressure, the mean of which is mainly governed by the outflow tract resistance, while the pulse pressure is governed by both the endoleak resistance and the stent-graft compliance. The study confirms many of the previous experimental findings and helps to provide possible explanations for findings that on first sight were inconsistent within their described context.