Arterial pulsatility under phasic left ventricular assist device support

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
1 Downloads (Pure)

Abstract

The aim of this study is to understand whether the phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support would increase the arterial pulsatility. A Micromed DeBakey CF-LVAD was used to apply phasic support in an ex-vivo experimental platform. CF-LVAD was operated over a cardiac cycle by phase-shifting the pulsatile pump control with respect to the heart cycle, in 0.05 s increments in each experiment. The pump flow rate was selected as the control variable and a reference model was used to operate the CF-LVAD at a pulsatile speed. Arterial pulse pressure was the highest (9 mmHg) when the peak pump flow is applied at the peak systole under varying speed CF-LVAD support over a cardiac cycle while it was the lowest (2 mmHg) when the peak pump flow was applied in the diastolic phase. The mean arterial pressure and mean CF-LVAD output were the same in each experiment while arterial pulse pressure and pulsatility index varied depending on the phase of reference pump flow rate signal. CF-LVAD speed should be synchronized considering the timing of peak systole over a cardiac cycle to increase the arterial pulsatility. Moreover, it is possible to decrease the arterial pulsatility under counter-pulsating CF-LVAD support.
Original languageEnglish
Pages (from-to)451-460
JournalBio-medical Materials and Engineering
Volume27
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • CF-LVAD
  • varying speed
  • pulsatility
  • phasic CF-LVAD support

Cite this

@article{2738fd6aef434145a7381a5ee0297a3e,
title = "Arterial pulsatility under phasic left ventricular assist device support",
abstract = "The aim of this study is to understand whether the phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support would increase the arterial pulsatility. A Micromed DeBakey CF-LVAD was used to apply phasic support in an ex-vivo experimental platform. CF-LVAD was operated over a cardiac cycle by phase-shifting the pulsatile pump control with respect to the heart cycle, in 0.05 s increments in each experiment. The pump flow rate was selected as the control variable and a reference model was used to operate the CF-LVAD at a pulsatile speed. Arterial pulse pressure was the highest (9 mmHg) when the peak pump flow is applied at the peak systole under varying speed CF-LVAD support over a cardiac cycle while it was the lowest (2 mmHg) when the peak pump flow was applied in the diastolic phase. The mean arterial pressure and mean CF-LVAD output were the same in each experiment while arterial pulse pressure and pulsatility index varied depending on the phase of reference pump flow rate signal. CF-LVAD speed should be synchronized considering the timing of peak systole over a cardiac cycle to increase the arterial pulsatility. Moreover, it is possible to decrease the arterial pulsatility under counter-pulsating CF-LVAD support.",
keywords = "CF-LVAD, varying speed, pulsatility, phasic CF-LVAD support",
author = "S. Bozkurt and {van Tuijl}, S. and {van de Vosse}, F.N. and M.C.M. Rutten",
year = "2016",
doi = "10.3233/BME-161599",
language = "English",
volume = "27",
pages = "451--460",
journal = "Bio-medical Materials and Engineering",
issn = "0959-2989",
publisher = "IOS Press",
number = "5",

}

Arterial pulsatility under phasic left ventricular assist device support. / Bozkurt, S.; van Tuijl, S.; van de Vosse, F.N.; Rutten, M.C.M.

In: Bio-medical Materials and Engineering, Vol. 27, No. 5, 2016, p. 451-460.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Arterial pulsatility under phasic left ventricular assist device support

AU - Bozkurt, S.

AU - van Tuijl, S.

AU - van de Vosse, F.N.

AU - Rutten, M.C.M.

PY - 2016

Y1 - 2016

N2 - The aim of this study is to understand whether the phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support would increase the arterial pulsatility. A Micromed DeBakey CF-LVAD was used to apply phasic support in an ex-vivo experimental platform. CF-LVAD was operated over a cardiac cycle by phase-shifting the pulsatile pump control with respect to the heart cycle, in 0.05 s increments in each experiment. The pump flow rate was selected as the control variable and a reference model was used to operate the CF-LVAD at a pulsatile speed. Arterial pulse pressure was the highest (9 mmHg) when the peak pump flow is applied at the peak systole under varying speed CF-LVAD support over a cardiac cycle while it was the lowest (2 mmHg) when the peak pump flow was applied in the diastolic phase. The mean arterial pressure and mean CF-LVAD output were the same in each experiment while arterial pulse pressure and pulsatility index varied depending on the phase of reference pump flow rate signal. CF-LVAD speed should be synchronized considering the timing of peak systole over a cardiac cycle to increase the arterial pulsatility. Moreover, it is possible to decrease the arterial pulsatility under counter-pulsating CF-LVAD support.

AB - The aim of this study is to understand whether the phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support would increase the arterial pulsatility. A Micromed DeBakey CF-LVAD was used to apply phasic support in an ex-vivo experimental platform. CF-LVAD was operated over a cardiac cycle by phase-shifting the pulsatile pump control with respect to the heart cycle, in 0.05 s increments in each experiment. The pump flow rate was selected as the control variable and a reference model was used to operate the CF-LVAD at a pulsatile speed. Arterial pulse pressure was the highest (9 mmHg) when the peak pump flow is applied at the peak systole under varying speed CF-LVAD support over a cardiac cycle while it was the lowest (2 mmHg) when the peak pump flow was applied in the diastolic phase. The mean arterial pressure and mean CF-LVAD output were the same in each experiment while arterial pulse pressure and pulsatility index varied depending on the phase of reference pump flow rate signal. CF-LVAD speed should be synchronized considering the timing of peak systole over a cardiac cycle to increase the arterial pulsatility. Moreover, it is possible to decrease the arterial pulsatility under counter-pulsating CF-LVAD support.

KW - CF-LVAD

KW - varying speed

KW - pulsatility

KW - phasic CF-LVAD support

U2 - 10.3233/BME-161599

DO - 10.3233/BME-161599

M3 - Article

C2 - 27885993

VL - 27

SP - 451

EP - 460

JO - Bio-medical Materials and Engineering

JF - Bio-medical Materials and Engineering

SN - 0959-2989

IS - 5

ER -