Aqueous asymmetric aldol reactions in polymersome membranes

M.C.M. van Oers, W.S. Veldmate, J.C.M. van Hest, F.P.J.T. Rutjes

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)


l-Proline catalysts have been immobilised in the hydrophobic domain of a polymersome via a copper(i)-catalysed azide-alkyne cycloaddition (CuAAC) reaction. Utilisation of these nanoreactors in the asymmetric aldol reaction of cyclohexanone with 4-nitrobenzaldehyde afforded the corresponding β-hydroxyketones in quantitative yields and with excellent enantio- and diastereoselectivities. The polymersomes were recycled up to five times without any loss in activity or selectivity.

Original languageEnglish
Pages (from-to)5358-5361
Number of pages4
JournalPolymer Chemistry
Issue number30
Publication statusPublished - 14 Aug 2015
Externally publishedYes


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