Approximation of fast dynamics in kinetic networks using non-negative polynomials

K.M. Nauta, S. Weiland, A.C.P.M. Backx, A. Jokic

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)


Kinetic models of reaction networks often feature sets of fast-reacting species. If the slow timescale is of interest, these species can be assumed to be in equilibrium and a singular perturbation approximation can be used to render the dynamics of the slow reacting subsystem. However, to obtain a reduction in the number of equations that represent the dynamics of the reaction network, an explicit representation of the equilibrium species is required. In most cases the equilibrium relations are given in implicit form, and algebraic manipulations to obtain an explicit form are prohibitive. This paper examines the use of constrained polynomial fitting techniques to obtain an approximation of the explicit form that is consistent with the physical constraints of the reaction network. This approximation can be combined with the slow reacting subsystem to form a reduced-order representation of the reaction network which is physically consistent. This reduced-order representation can then be used for analysis and control of the kinetic network.
Original languageEnglish
Title of host publicationProc. IEEE Int. Conference on Control Applications, CCA 2007
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Number of pages6
ISBN (Print)978-1-4244-0442-1
Publication statusPublished - 2007
Event2007 IEEE International Conference on Control Applications (CCA 2007) - Singapore, Singapore
Duration: 1 Oct 20073 Oct 2007


Conference2007 IEEE International Conference on Control Applications (CCA 2007)
Abbreviated titleCCA 2007
OtherCCA 2007, Singapore, Singapore


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