Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Michel Verhoeven; S.N. Bystrova; L. Winnubst; H. Qureshi; T.D. Gruijl, de; R.J. Scheper; R. Luttge

doi:10.1016/j.mee.2012.07.022

Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Michel Verhoeven, S.N. Bystrova, L. Winnubst, H. Qureshi, T.D. Gruijl, de, R.J. Scheper, R. Luttge

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. © 2012 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	659-662
Number of pages	4
Journal	Microelectronic Engineering
Volume	98
DOIs	https://doi.org/10.1016/j.mee.2012.07.022
Publication status	Published - 2012
Externally published	Yes

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title = "Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model",

abstract = "Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. {\textcopyright} 2012 Elsevier B.V. All rights reserved.",

author = "Michel Verhoeven and S.N. Bystrova and L. Winnubst and H. Qureshi and {Gruijl, de}, T.D. and R.J. Scheper and R. Luttge",

year = "2012",

doi = "10.1016/j.mee.2012.07.022",

language = "English",

volume = "98",

pages = "659--662",

journal = "Microelectronic Engineering",

issn = "0167-9317",

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T1 - Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

AU - Verhoeven, Michel

AU - Bystrova, S.N.

AU - Winnubst, L.

AU - Qureshi, H.

AU - Gruijl, de, T.D.

AU - Scheper, R.J.

AU - Luttge, R.

PY - 2012

Y1 - 2012

N2 - Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. © 2012 Elsevier B.V. All rights reserved.

AB - Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. © 2012 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.mee.2012.07.022

DO - 10.1016/j.mee.2012.07.022

M3 - Article

VL - 98

SP - 659

EP - 662

JO - Microelectronic Engineering

JF - Microelectronic Engineering

SN - 0167-9317

ER -