Aortic valve function under support of a left ventricular assist device : continuous vs. dynamic speed support

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
6 Downloads (Pure)

Abstract

Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support. A Medtronic freestyle valve and a Micromed DeBakey CF-LVAD were tested in a mock circulatory system. First, the CF-LVAD was operated at constant speeds between 7500 and 11,500 rpm with 1000 rpm intervals. The mean pump outputs obtained from these tests were applied in varying speed CF-LVAD support mode using a reference model for the pump flow. The peak of the instantaneous pump flow was applied at peak systole and mid-diastole, respectively. Ejection durations and in the aortic valve were the longest when the peak pump flow was applied at mid-diastole among the CF-LVAD operating modes. Furthermore, mean aortic valve area over a cardiac cycle was highest when the peak pump flow was applied at mid-diastole. The results show that changing phase of the reference flow rate signal may reduce the effects of the CF-LVADs on altered aortic valve closing behavior, without compromising the overall pump support level.
Original languageEnglish
Pages (from-to)1727-1737
Number of pages11
JournalAnnals of Biomedical Engineering
Volume43
Issue number8
DOIs
Publication statusPublished - Aug 2015

Fingerprint

Left ventricular assist devices
Pumps
Plant shutdowns
Flow rate

Keywords

  • CF-LVAD
  • Aortic valve
  • Aortic valve insufficiency
  • Aortic valve area
  • Varying speed CF-LVAD support

Cite this

@article{c95ca96524af4c6bba1a1b22f81295d9,
title = "Aortic valve function under support of a left ventricular assist device : continuous vs. dynamic speed support",
abstract = "Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support. A Medtronic freestyle valve and a Micromed DeBakey CF-LVAD were tested in a mock circulatory system. First, the CF-LVAD was operated at constant speeds between 7500 and 11,500 rpm with 1000 rpm intervals. The mean pump outputs obtained from these tests were applied in varying speed CF-LVAD support mode using a reference model for the pump flow. The peak of the instantaneous pump flow was applied at peak systole and mid-diastole, respectively. Ejection durations and in the aortic valve were the longest when the peak pump flow was applied at mid-diastole among the CF-LVAD operating modes. Furthermore, mean aortic valve area over a cardiac cycle was highest when the peak pump flow was applied at mid-diastole. The results show that changing phase of the reference flow rate signal may reduce the effects of the CF-LVADs on altered aortic valve closing behavior, without compromising the overall pump support level.",
keywords = "CF-LVAD, Aortic valve, Aortic valve insufficiency, Aortic valve area, Varying speed CF-LVAD support",
author = "S. Bozkurt and {Vosse, van de}, F.N. and M.C.M. Rutten",
year = "2015",
month = "8",
doi = "10.1007/s10439-014-1204-4",
language = "English",
volume = "43",
pages = "1727--1737",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer",
number = "8",

}

Aortic valve function under support of a left ventricular assist device : continuous vs. dynamic speed support. / Bozkurt, S.; Vosse, van de, F.N.; Rutten, M.C.M.

In: Annals of Biomedical Engineering, Vol. 43, No. 8, 08.2015, p. 1727-1737.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Aortic valve function under support of a left ventricular assist device : continuous vs. dynamic speed support

AU - Bozkurt, S.

AU - Vosse, van de, F.N.

AU - Rutten, M.C.M.

PY - 2015/8

Y1 - 2015/8

N2 - Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support. A Medtronic freestyle valve and a Micromed DeBakey CF-LVAD were tested in a mock circulatory system. First, the CF-LVAD was operated at constant speeds between 7500 and 11,500 rpm with 1000 rpm intervals. The mean pump outputs obtained from these tests were applied in varying speed CF-LVAD support mode using a reference model for the pump flow. The peak of the instantaneous pump flow was applied at peak systole and mid-diastole, respectively. Ejection durations and in the aortic valve were the longest when the peak pump flow was applied at mid-diastole among the CF-LVAD operating modes. Furthermore, mean aortic valve area over a cardiac cycle was highest when the peak pump flow was applied at mid-diastole. The results show that changing phase of the reference flow rate signal may reduce the effects of the CF-LVADs on altered aortic valve closing behavior, without compromising the overall pump support level.

AB - Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support. A Medtronic freestyle valve and a Micromed DeBakey CF-LVAD were tested in a mock circulatory system. First, the CF-LVAD was operated at constant speeds between 7500 and 11,500 rpm with 1000 rpm intervals. The mean pump outputs obtained from these tests were applied in varying speed CF-LVAD support mode using a reference model for the pump flow. The peak of the instantaneous pump flow was applied at peak systole and mid-diastole, respectively. Ejection durations and in the aortic valve were the longest when the peak pump flow was applied at mid-diastole among the CF-LVAD operating modes. Furthermore, mean aortic valve area over a cardiac cycle was highest when the peak pump flow was applied at mid-diastole. The results show that changing phase of the reference flow rate signal may reduce the effects of the CF-LVADs on altered aortic valve closing behavior, without compromising the overall pump support level.

KW - CF-LVAD

KW - Aortic valve

KW - Aortic valve insufficiency

KW - Aortic valve area

KW - Varying speed CF-LVAD support

U2 - 10.1007/s10439-014-1204-4

DO - 10.1007/s10439-014-1204-4

M3 - Article

C2 - 25480480

VL - 43

SP - 1727

EP - 1737

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 8

ER -