Antibacterial effects of electrospun chitosan/poly(ethylene oxide) nanofibrous membranes loaded with chlorhexidine and silver

Jiankang Song, Stefan J.A. Remmers, Jinlong Shao, Eva Kolwijck, X. Frank Walboomers, John A. Jansen, Sander C.G. Leeuwenburgh, Fang Yang (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

To prevent percutaneous device associated infections (PDAIs), we prepared electrospun chitosan/poly(ethylene oxide) (PEO) nanofibrous membrane containing silver nanoparticles as an implantable delivery vehicle for the dual release of chlorhexidine and silver ions. We observed that the silver nanoparticles were distributed homogeneously throughout the fibers, and a fast release of chlorhexidine in 2days and a sustained release of silver ions for up to 28days. The antibacterial efficacy of the membranes against Staphylococcus aureus showed that the membranes exhibited an obvious inhibition zone upon loading with either chlorhexidine (20μg or more per membrane) or AgNO3 (1 and 5wt% to polymer). Furthermore, long-term antibacterial effect up to 4days was verified using membranes containing 5wt% AgNO3. The results suggest that the membranes have strong potential to act as an active antibacterial dressing for local delivery of antibacterial agents to prevent PDAIs.

Original languageEnglish
Pages (from-to)1357-1364
Number of pages8
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume12
Issue number5
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Anti-Bacterial Agents/pharmacology
  • Chitosan/pharmacology
  • Chlorhexidine/pharmacology
  • Ethylene Oxide
  • Infections
  • Nanofibers
  • Polyethylene Glycols
  • Silver/pharmacology
  • Staphylococcus aureus

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