TY - JOUR
T1 - Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
AU - Cioni, Bianca
AU - Zaalberg, Anniek
AU - van Beijnum, Judy R.
AU - Melis, Monique H.M.
AU - van Burgsteden, Johan
AU - Muraro, Mauro J.
AU - Hooijberg, Erik
AU - Peters, Dennis
AU - Hofland, Ingrid
AU - Lubeck, Yoni
AU - de Jong, Jeroen
AU - Sanders, Joyce
AU - Vivié, Judith
AU - van der Poel, Henk G.
AU - de Boer, Jan Paul
AU - Griffioen, Arjan W.
AU - Zwart, Wilbert
AU - Bergman, Andries M.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy.
AB - The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy.
UR - http://www.scopus.com/inward/record.url?scp=85090398759&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-18313-y
DO - 10.1038/s41467-020-18313-y
M3 - Article
C2 - 32908142
AN - SCOPUS:85090398759
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4498
ER -
