Abstract
Understanding cell/material interactions is essential to design functional cell-responsive materials. While the scientific literature abounds with formulations of biomimetic materials, only a fraction of them focused on mechanisms of the molecular interactions between cells and material. To provide new knowledge on the strategies for materials/cell recognition and binding, supramolecular benzene-1,3,5-tricarboxamide copolymers bearing benzoxaborole moieties are anchored on the surface of human erythrocytes via benzoxaborole/sialic-acid binding. This interaction based on both dynamic covalent and non-covalent chemistries is visualized in real time by means of total internal reflection fluorescence microscopy. Exploiting this imaging method, we observe that the functional copolymers specifically interact with the cell surface. An optimal fiber affinity towards the cells as a function of benzoxaborole concentration demonstrates the crucial role of multivalency in these cell/material interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 17229-17233 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 59 |
| Issue number | 39 |
| Early online date | 25 Jun 2020 |
| DOIs | |
| Publication status | Published - 21 Sept 2020 |
Funding
We thank Sandra Schoenmakers (ICMS, TU/e) for performing the cryo‐TEM imaging. This work was financially supported by the Dutch Ministry of Education, Culture and Science (Gravity programs 024.001.035 and 024.003.013) and the Swiss National Science Foundation (SNSF “Early PostDoc Mobility” P2EZP2178435). ‐
| Funders | Funder number |
|---|---|
| Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung | P2EZP2178435 |
| Ministerie van Onderwijs, Cultuur en Wetenschap | 024.003.013, 024.001.035 |
Keywords
- boronic acid
- cell/material interactions
- multivalency
- red blood cells
- supramolecular polymers