Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system

M.W.J.M. Musters; N.A.W. Riel, van

doi:10.1109/IEMBS.2004.1403825

Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system

M.W.J.M. Musters, N.A.W. Riel, van

Control Systems

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

It is generally accepted that aging of the vascular system plays an important role in cardiovascular disease (CVD). Recent experimental findings have indicated the involvement of the cytokine transforming growth factor-/spl beta//sub 1/ (TGF-/spl beta//sub 1/) in these vascular aging processes. This cytokine is, after binding to a cell receptor, associated with numerous cellular processes, including formation of the extracellular matrix (ECM, the biomolecular network that surrounds the cell). We implemented TGF-/spl beta//sub 1/ signaling and its effect on ECM formation with piecewise-linear differential equations (PLDEs), which have several advantageous properties over traditional continuous modeling. Aging of the system was simulated as a reduction in cell sensitivity for TGF-/spl beta//sub 1/. The model predicted a disturbed ECM balance during aging, which corresponds well to findings from the literature. The outcome of this hybrid approach was satisfactory and, therefore, we will continue modeling of various aging-related pathways with PLDEs in future research

Original language	English
Title of host publication	Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society
Place of Publication	San Francisco
Pages	2901-2904
DOIs	https://doi.org/10.1109/IEMBS.2004.1403825
Publication status	Published - 2004
Event	26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, United States Duration: 1 Sept 2004 → 5 Sept 2004 Conference number: 26

Conference

Conference	26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
Abbreviated title	EMBC 2004
Country/Territory	United States
City	San Francisco
Period	1/09/04 → 5/09/04

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/IEMBS.2004.1403825

Voeding en Gezond Ouder Worden
van Riel, N. A. W. (Project Manager), Musters, M. (Project member), Verrips, C. T. (Program Manager), van den Bosch, P. P. P. J. (Project member), op den Buijs, J. (Project member), Post, J. A. (Project member), Puras, A. (Project member), Braam, B. (Project member) & Joles, J. A. (Project member)
1/10/01 → 1/09/07
Project: Research direct

Cite this

@inproceedings{68a4d7242c204604b395a5c6707b4f43,

title = "Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system",

abstract = "It is generally accepted that aging of the vascular system plays an important role in cardiovascular disease (CVD). Recent experimental findings have indicated the involvement of the cytokine transforming growth factor-/spl beta//sub 1/ (TGF-/spl beta//sub 1/) in these vascular aging processes. This cytokine is, after binding to a cell receptor, associated with numerous cellular processes, including formation of the extracellular matrix (ECM, the biomolecular network that surrounds the cell). We implemented TGF-/spl beta//sub 1/ signaling and its effect on ECM formation with piecewise-linear differential equations (PLDEs), which have several advantageous properties over traditional continuous modeling. Aging of the system was simulated as a reduction in cell sensitivity for TGF-/spl beta//sub 1/. The model predicted a disturbed ECM balance during aging, which corresponds well to findings from the literature. The outcome of this hybrid approach was satisfactory and, therefore, we will continue modeling of various aging-related pathways with PLDEs in future research",

author = "M.W.J.M. Musters and {Riel, van}, N.A.W.",

year = "2004",

doi = "10.1109/IEMBS.2004.1403825",

language = "English",

isbn = "0-7803-8439-3",

pages = "2901--2904",

booktitle = "Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society",

note = "26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, EMBC 2004 ; Conference date: 01-09-2004 Through 05-09-2004",

}

Musters, MWJM & Riel, van, NAW 2004, Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system. in Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society. San Francisco, pp. 2901-2904, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, San Francisco, California, United States, 1/09/04. https://doi.org/10.1109/IEMBS.2004.1403825

Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system. / Musters, M.W.J.M.; Riel, van, N.A.W.
Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society. San Francisco, 2004. p. 2901-2904.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - Musters, M.W.J.M.

AU - Riel, van, N.A.W.

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PY - 2004

Y1 - 2004

N2 - It is generally accepted that aging of the vascular system plays an important role in cardiovascular disease (CVD). Recent experimental findings have indicated the involvement of the cytokine transforming growth factor-/spl beta//sub 1/ (TGF-/spl beta//sub 1/) in these vascular aging processes. This cytokine is, after binding to a cell receptor, associated with numerous cellular processes, including formation of the extracellular matrix (ECM, the biomolecular network that surrounds the cell). We implemented TGF-/spl beta//sub 1/ signaling and its effect on ECM formation with piecewise-linear differential equations (PLDEs), which have several advantageous properties over traditional continuous modeling. Aging of the system was simulated as a reduction in cell sensitivity for TGF-/spl beta//sub 1/. The model predicted a disturbed ECM balance during aging, which corresponds well to findings from the literature. The outcome of this hybrid approach was satisfactory and, therefore, we will continue modeling of various aging-related pathways with PLDEs in future research

AB - It is generally accepted that aging of the vascular system plays an important role in cardiovascular disease (CVD). Recent experimental findings have indicated the involvement of the cytokine transforming growth factor-/spl beta//sub 1/ (TGF-/spl beta//sub 1/) in these vascular aging processes. This cytokine is, after binding to a cell receptor, associated with numerous cellular processes, including formation of the extracellular matrix (ECM, the biomolecular network that surrounds the cell). We implemented TGF-/spl beta//sub 1/ signaling and its effect on ECM formation with piecewise-linear differential equations (PLDEs), which have several advantageous properties over traditional continuous modeling. Aging of the system was simulated as a reduction in cell sensitivity for TGF-/spl beta//sub 1/. The model predicted a disturbed ECM balance during aging, which corresponds well to findings from the literature. The outcome of this hybrid approach was satisfactory and, therefore, we will continue modeling of various aging-related pathways with PLDEs in future research

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M3 - Conference contribution

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SN - 0-7803-8439-3

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BT - Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society

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ER -

Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system

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Voeding en Gezond Ouder Worden

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