An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart

A.C.H. Pape; M.H. Bakker; C.C.S. Tseng; M.M.C. Bastings; S. Koudstaal; P. Agostoni; S.A.J. Chamuleau; P.Y.W. Dankers

doi:10.3791/52450

An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart

A.C.H. Pape
, M.H. Bakker
, C.C.S. Tseng
, M.M.C. Bastings
, S. Koudstaal
, P. Agostoni
, S.A.J. Chamuleau
, P.Y.W. Dankers

Institute for Complex Molecular Systems

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

279 Downloads (Pure)

Abstract

Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.

Original language	English
Journal	Journal of Visualized Experiments (JoVE)
Issue number	100
DOIs	https://doi.org/10.3791/52450
Publication status	Published - Jun 2015

Keywords

Bioengineering
Issue 100
supramolecular polymers
hydrogels
catheter injection
drug delivery
pH switchability
pig model

Access to Document

10.3791/52450

publisher versionFinal published version, 1.92 MB

Cite this

@article{eac59da36fa14dfc82ed0b72c4085397,

title = "An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart",

abstract = "Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol{\textendash}gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.",

keywords = "Bioengineering, Issue 100, supramolecular polymers, hydrogels, catheter injection, drug delivery, pH switchability, pig model",

author = "A.C.H. Pape and M.H. Bakker and C.C.S. Tseng and M.M.C. Bastings and S. Koudstaal and P. Agostoni and S.A.J. Chamuleau and P.Y.W. Dankers",

year = "2015",

month = jun,

doi = "10.3791/52450",

language = "English",

journal = "Journal of Visualized Experiments (JoVE)",

issn = "1940-087X",

publisher = "MYJoVE Corporation",

number = "100",

}

TY - JOUR

T1 - An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart

AU - Pape, A.C.H.

AU - Bakker, M.H.

AU - Tseng, C.C.S.

AU - Bastings, M.M.C.

AU - Koudstaal, S.

AU - Agostoni, P.

AU - Chamuleau, S.A.J.

AU - Dankers, P.Y.W.

PY - 2015/6

Y1 - 2015/6

N2 - Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.

AB - Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.

KW - Bioengineering

KW - Issue 100

KW - supramolecular polymers

KW - hydrogels

KW - catheter injection

KW - drug delivery

KW - pH switchability

KW - pig model

UR - http://www.jove.com/video/52450/an-injectable-drug-loaded-supramolecular-hydrogel-for-local-catheter

U2 - 10.3791/52450

DO - 10.3791/52450

M3 - Article

C2 - 26132631

SN - 1940-087X

JO - Journal of Visualized Experiments (JoVE)

JF - Journal of Visualized Experiments (JoVE)

IS - 100

ER -

An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this