An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy

Debra S. Rivera, Mark S. Cohen, W. Gilbert Clark, Allen C. Chu, Ray L. Nunnally, Jolinda Smith, Dixie Mills, Jack W. Judy

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Miniature solenoids routinely enhance small volume nuclear magnetic resonance imaging and spectroscopy; however, no such techniques exist for patients. We present an implantable microcoil for diverse clinical applications, with a microliter coil volume. The design is loosely based on implantable depth electrodes, in which a flexible tube serves as the substrate, and a metal stylet is inserted into the tube during implantation. The goal is to provide enhanced signal-to-noise ratio (SNR) of structures that are not easily accessed by surface coils. The first-generation prototype was designed for implantation up to 2 cm, and provided initial proof-of-concept for microscopy. Subsequently, we optimized the design to minimize the influence of lead inductances, and to thereby double the length of the implantable depth (4 cm). The second-generation design represents an estimated SNR improvement of over 30 as compared to the original design when extended to 4 cm. Impedance measurements indicate that the device is stable for up to 24h in body temperature saline. We evaluated the SNR and MR-related heating of the device at 3T. The implantable microcoil can differentiate fat and water peaks, and resolve submillimeter features.

Original languageEnglish
Article number6095609
Pages (from-to)2118-2125
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number8
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Implantable biomedical devices
  • microscopy
  • neural microtechnology
  • nuclear imaging

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