An evolutionary-type model for tumor immunotherapy

A.I. Doban; M. Lazar

doi:10.1016/j.ifacol.2015.10.203

An evolutionary-type model for tumor immunotherapy

A.I. Doban, M. Lazar

Research output: Contribution to journal › Conference article › peer-review

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Abstract

In this paper we propose a new dynamical model for describing the interactions between immune and tumor cells. This model captures the effects of the tumor cells on the immune system and viceversa, through predator-prey competition terms. Additionally, it incorporates the immune system's mechanism to produce hunting immune cells, which makes the model suitable for immunotherapy strategies analysis and design. Consequently, we propose an approach based on Lyapunov functions in order to compute domains of attraction of equilibria of interest

Original language	English
Pages (from-to)	575-580
Journal	IFAC-PapersOnLine
Volume	48
Issue number	20
DOIs	https://doi.org/10.1016/j.ifacol.2015.10.203
Publication status	Published - 2015
Event	9th IFAC Symposium on Biological and Medical Systems (BMS 2015), August 31-September 2, 2015, Berlin, Germany - Berlin, Germany Duration: 31 Aug 2015 → 2 Sept 2015 http://www.bms2015.org/

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10.1016/j.ifacol.2015.10.203

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title = "An evolutionary-type model for tumor immunotherapy",

abstract = "In this paper we propose a new dynamical model for describing the interactions between immune and tumor cells. This model captures the effects of the tumor cells on the immune system and viceversa, through predator-prey competition terms. Additionally, it incorporates the immune system's mechanism to produce hunting immune cells, which makes the model suitable for immunotherapy strategies analysis and design. Consequently, we propose an approach based on Lyapunov functions in order to compute domains of attraction of equilibria of interest",

author = "A.I. Doban and M. Lazar",

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AU - Doban, A.I.

AU - Lazar, M.

PY - 2015

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N2 - In this paper we propose a new dynamical model for describing the interactions between immune and tumor cells. This model captures the effects of the tumor cells on the immune system and viceversa, through predator-prey competition terms. Additionally, it incorporates the immune system's mechanism to produce hunting immune cells, which makes the model suitable for immunotherapy strategies analysis and design. Consequently, we propose an approach based on Lyapunov functions in order to compute domains of attraction of equilibria of interest

AB - In this paper we propose a new dynamical model for describing the interactions between immune and tumor cells. This model captures the effects of the tumor cells on the immune system and viceversa, through predator-prey competition terms. Additionally, it incorporates the immune system's mechanism to produce hunting immune cells, which makes the model suitable for immunotherapy strategies analysis and design. Consequently, we propose an approach based on Lyapunov functions in order to compute domains of attraction of equilibria of interest

U2 - 10.1016/j.ifacol.2015.10.203

DO - 10.1016/j.ifacol.2015.10.203

M3 - Conference article

SN - 2405-8963

VL - 48

SP - 575

EP - 580

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

IS - 20

T2 - 9th IFAC Symposium on Biological and Medical Systems (BMS 2015), August 31-September 2, 2015, Berlin, Germany

Y2 - 31 August 2015 through 2 September 2015

ER -

An evolutionary-type model for tumor immunotherapy

Abstract

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