Abstract
Reaction conditions have been identified to conduct a one-pot asymmetric organocatalytic aldol reaction with a hydrophobic substrate in aqueous medium via a process running in flow mode. By employing a mixture of water and 2-propanol, a hydrophobic aldehyde and 3.6 mol% of an organocatalyst, this microreactor process affords the desired aldol adduct with a conversion of 74% and an enantioselectivity of 89% after a reaction time of 60 minutes.
Original language | English |
---|---|
Pages (from-to) | 1178-1184 |
Number of pages | 7 |
Journal | Synthesis |
Volume | 51 |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 2019 |
Keywords
- aldol reaction
- asymmetric catalysis
- continuously running processes
- flow chemistry
- organocatalysis
- water