Altered circadian rhythm of melatonin concentrations in hypocretin-deficient men

C.E.H.M. Donjacour, A. Kalsbeek, S. Overeem, G.J. Lammers, P. Pévet, B. Bothorel, H. Pijl, N.A. Aziz

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
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Hypocretin deficiency causes narcolepsy. It is unknown whether melatonin secretion is affected in this sleep disorder. Therefore, in both narcolepsy patients and matched controls, the authors measured plasma melatonin levels hourly for 24 h before and after 5 days of sodium oxybate (SXB) administration. Although mean melatonin concentrations were similar between patients and controls, in narcoleptics the percentage of 24-h melatonin secreted during the daytime was significantly higher, and melatonin secretion exhibited a weaker coupling to sleep. SXB did not affect melatonin secretion. These findings suggest that hypocretin deficiency might disturb both the circadian control of melatonin release and its temporal association with sleep.

Original languageEnglish
Pages (from-to)356-362
Number of pages7
JournalChronobiology International
Issue number3
Publication statusPublished - Apr 2012
Externally publishedYes


  • Adult
  • Case-Control Studies
  • Circadian Rhythm
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Melatonin
  • Narcolepsy
  • Neuropeptides
  • Orexins
  • Sleep
  • Sleep Disorders, Circadian Rhythm
  • Sodium Oxybate
  • Journal Article
  • Research Support, Non-U.S. Gov't


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