Abstract
Allostery is a basic principle of control of enzymatic activities based on the interaction of a protein or small molecule at a site distinct from an enzyme's active center. Allosteric modulators represent an alternative approach to the design and synthesis of small-molecule activators or inhibitors of proteases and are therefore of wide interest for medicinal chemistry. The structural bases of some proteinaceous and small-molecule allosteric protease regulators have already been elucidated, indicating a general mechanism that might be exploitable for future rational design of small-molecule effectors
| Original language | English |
|---|---|
| Pages (from-to) | 2920-2980 |
| Journal | ChemBioChem |
| Volume | 8 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2008 |