Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

María J. Sánchez-Fernández, Mikey R. Immers, Rosa P. Félix Lanao, Fang Yang, Johan C.M.E. Bender, Jasmin Mecinović, Sander C.G. Leeuwenburgh (Corresponding author), Jan C.M. van Hest (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca2+-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (KCa 2+ = 2.4 × 105 M-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.

LanguageEnglish
Pages2913-2921
Number of pages9
JournalBiomacromolecules
Volume20
Issue number8
DOIs
StatePublished - 1 Jan 2019

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Alendronate
Cations
Calcium
Polymers
Positive ions
Hydrogels
Hydrogel
Calorimetry
Carboxylic Acids
Titration
Rheology
Carboxylic acids
Hydroxyl Radical
poly(2-oxazoline)
Elastic moduli
Thermodynamics

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Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., ... van Hest, J. C. M. (2019). Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations. Biomacromolecules, 20(8), 2913-2921. DOI: 10.1021/acs.biomac.9b00104
Sánchez-Fernández, María J. ; Immers, Mikey R. ; Félix Lanao, Rosa P. ; Yang, Fang ; Bender, Johan C.M.E. ; Mecinović, Jasmin ; Leeuwenburgh, Sander C.G. ; van Hest, Jan C.M./ Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations. In: Biomacromolecules. 2019 ; Vol. 20, No. 8. pp. 2913-2921
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abstract = "A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca2+-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (KCa 2+ = 2.4 × 105 M-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100{\%} of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.",
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Sánchez-Fernández, MJ, Immers, MR, Félix Lanao, RP, Yang, F, Bender, JCME, Mecinović, J, Leeuwenburgh, SCG & van Hest, JCM 2019, 'Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations' Biomacromolecules, vol. 20, no. 8, pp. 2913-2921. DOI: 10.1021/acs.biomac.9b00104

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations. / Sánchez-Fernández, María J.; Immers, Mikey R.; Félix Lanao, Rosa P.; Yang, Fang; Bender, Johan C.M.E.; Mecinović, Jasmin; Leeuwenburgh, Sander C.G. (Corresponding author); van Hest, Jan C.M. (Corresponding author).

In: Biomacromolecules, Vol. 20, No. 8, 01.01.2019, p. 2913-2921.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Sánchez-Fernández,María J.

AU - Immers,Mikey R.

AU - Félix Lanao,Rosa P.

AU - Yang,Fang

AU - Bender,Johan C.M.E.

AU - Mecinović,Jasmin

AU - Leeuwenburgh,Sander C.G.

AU - van Hest,Jan C.M.

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N2 - A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca2+-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (KCa 2+ = 2.4 × 105 M-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.

AB - A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca2+-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (KCa 2+ = 2.4 × 105 M-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.

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Sánchez-Fernández MJ, Immers MR, Félix Lanao RP, Yang F, Bender JCME, Mecinović J et al. Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations. Biomacromolecules. 2019 Jan 1;20(8):2913-2921. Available from, DOI: 10.1021/acs.biomac.9b00104