Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle

N.M.B.K. Willems, L. Mulder, G.E.J. Langenbach, T. Grünheid, A. Zentner, T.M.G.J. Eijden, van

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Abstract

The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 microm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.
Original languageEnglish
Pages (from-to)421-427
JournalJournal of Structural Biology
Volume158
Issue number3
DOIs
Publication statusPublished - 2007

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Mandibular Condyle
Swine
Postpartum Period
Bone and Bones
X-Ray Microtomography
Bone Development
Growth and Development
Growth
Cancellous Bone

Cite this

Willems, N. M. B. K., Mulder, L., Langenbach, G. E. J., Grünheid, T., Zentner, A., & Eijden, van, T. M. G. J. (2007). Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle. Journal of Structural Biology, 158(3), 421-427. https://doi.org/10.1016/j.jsb.2006.12.011
Willems, N.M.B.K. ; Mulder, L. ; Langenbach, G.E.J. ; Grünheid, T. ; Zentner, A. ; Eijden, van, T.M.G.J. / Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle. In: Journal of Structural Biology. 2007 ; Vol. 158, No. 3. pp. 421-427.
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abstract = "The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 microm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.",
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Willems, NMBK, Mulder, L, Langenbach, GEJ, Grünheid, T, Zentner, A & Eijden, van, TMGJ 2007, 'Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle', Journal of Structural Biology, vol. 158, no. 3, pp. 421-427. https://doi.org/10.1016/j.jsb.2006.12.011

Age-related changes in microarchitecture and mineralization of cancellous bone in the porcine mandibular condyle. / Willems, N.M.B.K.; Mulder, L.; Langenbach, G.E.J.; Grünheid, T.; Zentner, A.; Eijden, van, T.M.G.J.

In: Journal of Structural Biology, Vol. 158, No. 3, 2007, p. 421-427.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Zentner, A.

AU - Eijden, van, T.M.G.J.

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AB - The mandibular condyle is considered a good model for developing cancellous bone because of its rapid growth and high rate of remodeling. The aim of the present study was to analyze the simultaneous changes in microarchitecture and mineralization of cancellous bone during development in a three-dimensional fashion. Eight mandibular condyles of pigs aged 8 weeks prepartum to 108 weeks postpartum were scanned using microCT with an isotropic spatial resolution of 10 microm. The number of trabeculae decreased during development, whereas both the trabecular thickness and the distance between the trabeculae increased. The bone surface to volume ratio decreased during development, possibly limiting the amount of (re)modeling. Both the mean degree of mineralization and intratrabecular differences in mineralization between the surfaces and cores of trabecular elements increased during development. The trabecular surfaces were more highly mineralized in the older condyles compared to the younger ones. Together with the observed decrease in the relative size of trabecular surface, this finding suggests a decrease in (re)modeling activity during development. In accordance with the general growth and development of the pig, it was concluded that most developmental changes in cancellous bone occur until the age of 40 weeks postpartum.

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