Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

H.P.L. Gemoets; V. Hessel; T. Noel

Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

H.P.L. Gemoets, V. Hessel, T. Noel

Micro Flow Chemistry and Synthetic Methodology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process

Original language	English
Title of host publication	Chains, Chemistry As Innovating Science 2014, 17-18 November 2014, Veldhoven, The Netherlands
Publication status	Published - 2014
Event	CHAINS 2014 (CHemistry As Innovating Science) - Koningshof, Veldhoven, Netherlands Duration: 17 Nov 2014 → 18 Nov 2014 http://www.chains2014.nl/

Conference

Conference	CHAINS 2014 (CHemistry As Innovating Science)
Abbreviated title	CHAINS 2014
Country/Territory	Netherlands
City	Veldhoven
Period	17/11/14 → 18/11/14
Internet address	http://www.chains2014.nl/

Bibliographical note

poster presentation

Cite this

@inproceedings{c0a3cca6f3fc4ee7be02877fc04708de,

title = "Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow",

abstract = "Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process",

author = "H.P.L. Gemoets and V. Hessel and T. Noel",

note = "poster presentation; CHAINS 2014 (CHemistry As Innovating Science), CHAINS 2014 ; Conference date: 17-11-2014 Through 18-11-2014",

year = "2014",

language = "English",

booktitle = "Chains, Chemistry As Innovating Science 2014, 17-18 November 2014, Veldhoven, The Netherlands",

url = "http://www.chains2014.nl/",

}

TY - GEN

T1 - Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

AU - Gemoets, H.P.L.

AU - Hessel, V.

AU - Noel, T.

N1 - poster presentation

PY - 2014

Y1 - 2014

N2 - Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process

AB - Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process

M3 - Conference contribution

BT - Chains, Chemistry As Innovating Science 2014, 17-18 November 2014, Veldhoven, The Netherlands

T2 - CHAINS 2014 (CHemistry As Innovating Science)

Y2 - 17 November 2014 through 18 November 2014

ER -

Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

Abstract

Conference

Bibliographical note

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Cite this