Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

H.P.L. Gemoets, V. Hessel, T. Noel

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Abstract

Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process
Original languageEnglish
Title of host publicationChains, Chemistry As Innovating Science 2014, 17-18 November 2014, Veldhoven, The Netherlands
Publication statusPublished - 2014
EventCHAINS 2014 (CHemistry As Innovating Science) - Koningshof, Veldhoven, Netherlands
Duration: 17 Nov 201418 Nov 2014
http://www.chains2014.nl/

Conference

ConferenceCHAINS 2014 (CHemistry As Innovating Science)
Abbreviated titleCHAINS 2014
CountryNetherlands
CityVeldhoven
Period17/11/1418/11/14
Internet address

Bibliographical note

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    Gemoets, H. P. L., Hessel, V., & Noel, T. (2014). Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow. In Chains, Chemistry As Innovating Science 2014, 17-18 November 2014, Veldhoven, The Netherlands