Adsorptive membranes for bilirubin removal

M.E. Avramescu; W.F.C. Sager; Z. Borneman; M. Wessling

doi:10.1016/j.jchromb.2003.12.020

Adsorptive membranes for bilirubin removal

M.E. Avramescu
, W.F.C. Sager
, Z. Borneman
, M. Wessling

Research output: Contribution to journal › Article › Academic › peer-review

75 Citations (Scopus)

2 Downloads (Pure)

Abstract

In this study, we employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin (BR) retention. Microfiltration membranes were prepared from ternary or quaternary water/(1-octanol)/DMSO/EVAL systems. To obtain active binding sites for BSA, the EVAL membranes were either chemically functionalized in aqueous and organic medium and by plasma dischargement or physically activated by entrapping of active particles. Static BR removal was determined for all EVAL-BSA membranes. BR retentions relevant for human plasma were gained for the mixed adsorber membranes and additionally investigated in the dynamic mode.

Original language	English
Pages (from-to)	215-223
Number of pages	9
Journal	Journal of Chromatography, B, Analytical Technologies in the Biomedical and Life Sciences
Volume	803
Issue number	2
DOIs	https://doi.org/10.1016/j.jchromb.2003.12.020
Publication status	Published - 25 Apr 2004

Keywords

Adsorptive membranes
Bilirubin

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10.1016/j.jchromb.2003.12.020

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AU - Avramescu, M.E.

AU - Sager, W.F.C.

AU - Borneman, Z.

AU - Wessling, M.

PY - 2004/4/25

Y1 - 2004/4/25

N2 - In this study, we employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin (BR) retention. Microfiltration membranes were prepared from ternary or quaternary water/(1-octanol)/DMSO/EVAL systems. To obtain active binding sites for BSA, the EVAL membranes were either chemically functionalized in aqueous and organic medium and by plasma dischargement or physically activated by entrapping of active particles. Static BR removal was determined for all EVAL-BSA membranes. BR retentions relevant for human plasma were gained for the mixed adsorber membranes and additionally investigated in the dynamic mode.

AB - In this study, we employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin (BR) retention. Microfiltration membranes were prepared from ternary or quaternary water/(1-octanol)/DMSO/EVAL systems. To obtain active binding sites for BSA, the EVAL membranes were either chemically functionalized in aqueous and organic medium and by plasma dischargement or physically activated by entrapping of active particles. Static BR removal was determined for all EVAL-BSA membranes. BR retentions relevant for human plasma were gained for the mixed adsorber membranes and additionally investigated in the dynamic mode.

KW - Adsorptive membranes

KW - Bilirubin

UR - https://www.scopus.com/pages/publications/1842531410

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SN - 1570-0232

VL - 803

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JO - Journal of Chromatography, B, Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography, B, Analytical Technologies in the Biomedical and Life Sciences

IS - 2

ER -

Adsorptive membranes for bilirubin removal

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Keywords

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