Adsorptive membranes for bilirubin removal

M.E. Avramescu, W.F.C. Sager, Z. Borneman, M. Wessling

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In this study, we employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin (BR) retention. Microfiltration membranes were prepared from ternary or quaternary water/(1-octanol)/DMSO/EVAL systems. To obtain active binding sites for BSA, the EVAL membranes were either chemically functionalized in aqueous and organic medium and by plasma dischargement or physically activated by entrapping of active particles. Static BR removal was determined for all EVAL-BSA membranes. BR retentions relevant for human plasma were gained for the mixed adsorber membranes and additionally investigated in the dynamic mode.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalJournal of Chromatography, B, Analytical Technologies in the Biomedical and Life Sciences
Issue number2
Publication statusPublished - 25 Apr 2004


  • Adsorptive membranes
  • Bilirubin


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