Additional filtering of blood from a cell salvage device is not likely to show important additional benefits in outcome in cardiac surgery

Adrianus J. de Vries (Corresponding author), Wytze J. Vermeijden, L. Joost van Pelt, Edwin R. van den Heuvel, Willem van Oeveren

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


BACKGROUND: Several authors and manufacturers of cell salvage devices recommend additional filtering of processed blood before transfusion. There is no evidence to support this practice. Therefore, we compared the clinical outcome and biochemical effects of cell salvage with or without additional filtering. STUDY DESIGN AND METHODS: The patients, scheduled for coronary artery bypass grafting, valve replacement, or combined procedures were part of our randomized multicenter factorial study of cell salvage and filter use on transfusion requirements (ISRCTN 58333401). They were randomized to intraoperative cell salvage or cell salvage plus additional WBC depletion filter. We compared the occurrence of major adverse events (combined death/stroke/myocardial infarction) as primary outcome and minor adverse events (renal function disturbances, infections, delirium), ventilation time, and length of stay in the intensive care unit and hospital. We also measured biochemical markers of organ injury and inflammation. RESULTS: One hundred eighty-nine patients had cell salvage, and 175 patients had cell salvage plus filter and completed the study. Demographic data, surgical procedures, and amount of salvaged blood were not different between the groups. There was no difference in the primary outcome with a risk of 6.3% (95% confidence interval [CI], 3.34–11.25) in the cell salvage plus filter group versus 5.8% (95% CI, 3.09–10.45) in the cell salvage group, a relative risk of 1.08 (95% CI, 0.48– 2.43]. There were no differences in minor adverse events and biochemical markers between the groups. CONCLUSION: The routine use of an additional filter for transfusion of salvaged blood is unlikely to show important additional benefits.

Original languageEnglish
Pages (from-to)989-994
Number of pages6
Issue number3
Publication statusPublished - Mar 2019


  • Aged
  • Blood Transfusion/methods
  • Cardiac Surgical Procedures/methods
  • Coronary Artery Bypass/methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction/surgery
  • Stroke/surgery
  • Treatment Outcome

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