Mechanical load plays an important role in cardiac growth and remodeling. In a previous mathematical model study the hypothesis was tested that fiber cross-fiber shear acts as a stimulus for remodeling of the pattern of myofiber orientations . It was found that reorientation in response to fiber cross-fiber shear yielded realistic longitudinal and transmural components of myofiber orientation. In this study, we investigated whether circumferential-radial shear, as determined experimentally with magnetic resonance tagging, can be reproduced in the model as well. Our results show that after myofiber reorientation differences in circumferential-radial shear between model and experiment were reduced significantly. However, a complete match could not be obtained through shear-induced myofiber reorientation alone.
|Title of host publication||Functional Imaging and Modeling of the Heart : proceedings of the 5th Intrenational conference (FIMH 2009), June 3-5, 2009, Nice France|
|Editors||N. Ayache, H. Delingette, M. Sermesant|
|Place of Publication||Berlin|
|Publication status||Published - 2009|
|Name||Lecture Notes in Computer Science|