Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Imke A. B. Pijpers, Loai K.E.A. Abdelmohsen, Yifeng Xia, Shoupeng Cao, David S. Williams, Fenghua Meng, Jan C.M. van Hest, Zhiyuan Zhong

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well‐defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof‐of‐concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.
LanguageEnglish
Article number1800068
Number of pages14
JournalAdvanced Therapeutics
Volume1
Issue number8
Early online date4 Sep 2018
DOIs
StatePublished - 1 Dec 2018

Fingerprint

Medical nanotechnology
Micelles
Nanoparticles
Fabrication
Drug delivery
Block copolymers

Cite this

@article{306dad2a50eb493795e6c5f3a08a0d3e,
title = "Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies",
abstract = "Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well‐defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof‐of‐concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.",
author = "Pijpers, {Imke A. B.} and Abdelmohsen, {Loai K.E.A.} and Yifeng Xia and Shoupeng Cao and Williams, {David S.} and Fenghua Meng and {van Hest}, {Jan C.M.} and Zhiyuan Zhong",
year = "2018",
month = "12",
day = "1",
doi = "10.1002/adtp.201800068",
language = "English",
volume = "1",
journal = "Advanced Therapeutics",
issn = "2366-3987",
publisher = "Wiley-VCH Verlag",
number = "8",

}

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies. / Pijpers, Imke A. B.; Abdelmohsen, Loai K.E.A.; Xia, Yifeng; Cao, Shoupeng; Williams, David S.; Meng, Fenghua; van Hest, Jan C.M.; Zhong, Zhiyuan.

In: Advanced Therapeutics, Vol. 1, No. 8, 1800068, 01.12.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

AU - Pijpers,Imke A. B.

AU - Abdelmohsen,Loai K.E.A.

AU - Xia,Yifeng

AU - Cao,Shoupeng

AU - Williams,David S.

AU - Meng,Fenghua

AU - van Hest,Jan C.M.

AU - Zhong,Zhiyuan

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well‐defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof‐of‐concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.

AB - Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well‐defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof‐of‐concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.

U2 - 10.1002/adtp.201800068

DO - 10.1002/adtp.201800068

M3 - Article

VL - 1

JO - Advanced Therapeutics

T2 - Advanced Therapeutics

JF - Advanced Therapeutics

SN - 2366-3987

IS - 8

M1 - 1800068

ER -