Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof-of-Concept Studies

Imke A.B. Pijpers, Loai K.E.A. Abdelmohsen, Yifeng Xia, Shoupeng Cao, David S. Williams, Fenghua Meng, Jan C.M. van Hest, Zhiyuan Zhong

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
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Abstract

Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well-defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof-of-concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.

Original languageEnglish
Article number1800068
Number of pages14
JournalAdvanced Therapeutics
Volume1
Issue number8
Early online date4 Sep 2018
DOIs
Publication statusPublished - 4 Sep 2018

Bibliographical note

Funding Information:
I.A.B.P. and L.K.E.A.A. have contributed equally to this work. The authors acknowledge support from the National Natural Science Foundation of China (NSFC 51561135010, 51773146, 51633005), the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035), NWO-NSFC Advanced Materials (project 792.001.015), the ERC Advanced grant Artisym (694120), and the European Union's Horizon 2020 research and innovation programme Marie Sk?odowska-Curie Innovative Training Networks (ITN) Nanomed, under grant No. 676137 for funding. D.S.W. thanks the Ser Cymru II programme for support; this project received funding from the European Union's Horizon 2020 research and innovation under the Marie Sk?odowska-Curie grant agreement No. 663830.

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • adaptive morphologies
  • drug delivery
  • nanomedicine
  • nanotechnology

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