Acute neuronal injury, excitotoxicity, and the endocannabinoid system

M. Stelt, van der, W.B. Veldhuis, M. Maccarrone, P.R. Bär, K. Nicolaij, G.A. Veldink, M. Di, V., J.F.G. Vliegenthart

Research output: Contribution to journalArticleAcademicpeer-review

118 Citations (Scopus)

Abstract

The endocannabinoid system is a valuable target for drug discovery, because it is involved in the regulation of many cellular and physiological functions. The endocannabinoid system constitutes the endogenous lipids anandamide, 2-arachidonoylglycerol and noladin ether, and the cannabinoid CB1 and CB2 receptors as well as the proteins for their inactivation. It is thought that (endo)cannabinoid-based drugs may potentially be useful to reduce the effects of neurodegeneration. This paper reviews recent developments in the endocannabinoid system and its involvement in neuroprotection. Exogenous (endo)cannabinoids have been shown to exert neuroprotection in a variety of in vitro and in vivo models of neuronal injury via different mechanisms, such as prevention of excitotoxicity by CB1-mediated inhibition of glutamatergic transmission, reduction of calcium influx, and subsequent inhibition of deleterious cascades, TNF-a formation, and anti-oxidant activity. It has been suggested that the release of endogenous endocannabinoids during neuronal injury might be a protective response. However, several observations indicate that the role of the endocannabinoid system as a general endogenous protection system is questionable. The data are critically reviewed and possible explanations are given
Original languageEnglish
Pages (from-to)317-346
JournalMolecular Neurobiology
Volume26
Issue number2-3
DOIs
Publication statusPublished - 2002

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Endocannabinoids
Wounds and Injuries
Cannabinoids
Cannabinoid Receptor CB2
Cannabinoid Receptor CB1
Drug Discovery
Oxidants
Calcium
Lipids
Pharmaceutical Preparations
Proteins

Cite this

Stelt, van der, M., Veldhuis, W. B., Maccarrone, M., Bär, P. R., Nicolaij, K., Veldink, G. A., ... Vliegenthart, J. F. G. (2002). Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Molecular Neurobiology, 26(2-3), 317-346. https://doi.org/10.1385/MN:26:2-3:317
Stelt, van der, M. ; Veldhuis, W.B. ; Maccarrone, M. ; Bär, P.R. ; Nicolaij, K. ; Veldink, G.A. ; Di, V., M. ; Vliegenthart, J.F.G. / Acute neuronal injury, excitotoxicity, and the endocannabinoid system. In: Molecular Neurobiology. 2002 ; Vol. 26, No. 2-3. pp. 317-346.
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Stelt, van der, M, Veldhuis, WB, Maccarrone, M, Bär, PR, Nicolaij, K, Veldink, GA, Di, V., M & Vliegenthart, JFG 2002, 'Acute neuronal injury, excitotoxicity, and the endocannabinoid system', Molecular Neurobiology, vol. 26, no. 2-3, pp. 317-346. https://doi.org/10.1385/MN:26:2-3:317

Acute neuronal injury, excitotoxicity, and the endocannabinoid system. / Stelt, van der, M.; Veldhuis, W.B.; Maccarrone, M.; Bär, P.R.; Nicolaij, K.; Veldink, G.A.; Di, V., M.; Vliegenthart, J.F.G.

In: Molecular Neurobiology, Vol. 26, No. 2-3, 2002, p. 317-346.

Research output: Contribution to journalArticleAcademicpeer-review

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Stelt, van der M, Veldhuis WB, Maccarrone M, Bär PR, Nicolaij K, Veldink GA et al. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Molecular Neurobiology. 2002;26(2-3):317-346. https://doi.org/10.1385/MN:26:2-3:317