Abstract
Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.
Original language | English |
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Pages (from-to) | 637-639 |
Number of pages | 3 |
Journal | ChemBioChem |
Volume | 11 |
Issue number | 5 |
DOIs | |
Publication status | Published - 22 Mar 2010 |
Keywords
- Benzamides/chemistry
- Caspase 3/chemistry
- Catalytic Domain
- Coumarins/chemistry
- Enzyme Precursors/chemistry
- Hydrazones/chemistry
- Piperazines/chemistry
- Protein Binding
- Protein Structure, Tertiary