Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Christian Ottmann; Patrick Hauske; Markus Kaiser

doi:10.1002/cbic.201000024

Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Christian Ottmann, Patrick Hauske, Markus Kaiser (Corresponding author)

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

Original language	English
Pages (from-to)	637-639
Number of pages	3
Journal	ChemBioChem
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/cbic.201000024
Publication status	Published - 22 Mar 2010

Keywords

Benzamides/chemistry
Caspase 3/chemistry
Catalytic Domain
Coumarins/chemistry
Enzyme Precursors/chemistry
Hydrazones/chemistry
Piperazines/chemistry
Protein Binding
Protein Structure, Tertiary

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10.1002/cbic.201000024

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title = "Activation instead of inhibition: targeting proenzymes for small-molecule intervention",

abstract = "Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.",

keywords = "Benzamides/chemistry, Caspase 3/chemistry, Catalytic Domain, Coumarins/chemistry, Enzyme Precursors/chemistry, Hydrazones/chemistry, Piperazines/chemistry, Protein Binding, Protein Structure, Tertiary",

author = "Christian Ottmann and Patrick Hauske and Markus Kaiser",

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journal = "ChemBioChem",

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AU - Ottmann, Christian

AU - Hauske, Patrick

AU - Kaiser, Markus

PY - 2010/3/22

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N2 - Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

AB - Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

KW - Benzamides/chemistry

KW - Caspase 3/chemistry

KW - Catalytic Domain

KW - Coumarins/chemistry

KW - Enzyme Precursors/chemistry

KW - Hydrazones/chemistry

KW - Piperazines/chemistry

KW - Protein Binding

KW - Protein Structure, Tertiary

U2 - 10.1002/cbic.201000024

DO - 10.1002/cbic.201000024

M3 - Article

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SP - 637

EP - 639

JO - ChemBioChem

JF - ChemBioChem

SN - 1439-4227

IS - 5

ER -

Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Abstract

Keywords

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