Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Christian Ottmann, Patrick Hauske, Markus Kaiser (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.
Original languageEnglish
Pages (from-to)637-639
Number of pages3
JournalChemBioChem
Volume11
Issue number5
DOIs
Publication statusPublished - 22 Mar 2010

Keywords

  • Benzamides/chemistry
  • Caspase 3/chemistry
  • Catalytic Domain
  • Coumarins/chemistry
  • Enzyme Precursors/chemistry
  • Hydrazones/chemistry
  • Piperazines/chemistry
  • Protein Binding
  • Protein Structure, Tertiary

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