Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy

Bingbing Sun, Rui Chang, Shoupeng Cao, Chengqian Yuan, Luyang Zhao, Haowen Yang, Junbai Li, Xuehai Yan (Corresponding author), Jan C.M. van Hest (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

135 Citations (Scopus)

Abstract

Inspired by the dynamic morphology control of molecular assemblies in biological systems, we have developed pH-responsive transformable peptide-based nanoparticles for photodynamic therapy (PDT) with prolonged tumor retention times. The self-assembled peptide–porphyrin nanoparticles transformed into nanofibers when exposed to the acidic tumor microenvironment, which was mainly driven by enhanced intermolecular hydrogen bond formation between the protonated molecules. The nanoparticle transformation into fibrils improved their singlet oxygen generation ability and enabled high accumulation and long-term retention at tumor sites. Strong fluorescent signals of these nanomaterials were detected in tumor tissue up to 7 days after administration. Moreover, the peptide assemblies exhibited excellent anti-tumor efficacy via PDT in vivo. This in situ fibrillar transformation strategy could be utilized to design effective stimuli-responsive biomaterials for long-term imaging and therapy.

Original languageEnglish
Pages (from-to)20582-20588
Number of pages7
JournalAngewandte Chemie - International Edition
Volume59
Issue number46
Early online date20 Jul 2020
DOIs
Publication statusPublished - 9 Nov 2020

Funding

We acknowledge financial support from the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035) and the Eurotech Postdoc Programme, under the Marie Skłodowska‐Curie grant agreement No 754462 as well as the National Natural Science Fund BRICS STI Framework Programme of China (No. 51861145304), Innovation Research Community Science Fund of National Natural Science Foundation of China (No. 21821005), and the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS, Grant No. QYZDB‐SSW‐JSC034). All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee in compliance with Chinese law for experimental animals with an approval number of IPEAECA2019106. We acknowledge financial support from the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035) and the Eurotech Postdoc Programme, under the Marie Skłodowska-Curie grant agreement No 754462 as well as the National Natural Science Fund BRICS STI Framework Programme of China (No. 51861145304), Innovation Research Community Science Fund of National Natural Science Foundation of China (No. 21821005), and the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS, Grant No. QYZDB-SSW-JSC034). All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee in compliance with Chinese law for experimental animals with an approval number of IPEAECA2019106.

FundersFunder number
Eurotech Postdoc Programme
Guide for the CareIPEAECA2019106
Innovation Research Community Science Fund of National Natural Science Foundation of China21821005
STI Framework Programme of China51861145304
Horizon 2020 Framework Programme
Marie Skłodowska‐Curie754462
Chinese Academy of SciencesQYZDB‐SSW‐JSC034
Ministerie van Onderwijs, Cultuur en Wetenschap024.001.035

    Keywords

    • fibrillar transformation
    • peptides
    • photodynamic therapy
    • photosensitizers
    • self-assembly

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