Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology

Rogier R. Wildeboer, Ruud J.G. van Sloun, Arnoud W. Postema, Christophe K. Mannaerts, Maudy Gayet, Harrie P. Beerlage, Hessel Wijkstra, Massimo Mischi

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)
94 Downloads (Pure)

Abstract

As the development of modalities for prostate cancer (PCa) imaging advances, the challenge of accurate registration between images and histopathologic ground truth becomes more pressing. Localization of PCa, rather than detection, requires a pixel-to-pixel validation of imaging based on histopathology after radical prostatectomy. Such a registration procedure is challenging for ultrasound modalities; not only the deformations of the prostate after resection have to be taken into account, but also the deformation due to the employed transrectal probe and the mismatch in orientation between imaging planes and pathology slices. In this work, we review the latest techniques to facilitate accurate validation of PCa localization in ultrasound imaging studies and extrapolate a general strategy for implementation of a registration procedure.

Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalJournal of Ultrasound
Volume21
Issue number3
DOIs
Publication statusPublished - Sep 2018

Keywords

  • Diagnostic imaging
  • Histology
  • Prostate cancer
  • Review
  • Validation studies as topic

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