Accuracy assessment of CBCT-based volumetric brain shift field

I.M. Ockeloen, D. Ruijters, M. Breeuwer, D. Babic, O. Brina, V.M. Pereira

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)


The displacement of the brain parenchyma during open brain surgery, known as ‘brain shift’, affects the applicability of pre-operative planning and affects the outcome of the surgery. In this article we investigated the accuracy of a novel method to intra-operatively determine the brain shift displacement field throughout the whole brain volume. The brain shift displacement was determined by acquiring contrast enhanced cone-beam CT before and during the surgery. The respective datasets were pre-processed, landmark enhanced, and elastically registered to find the displacement field. The accuracy of this method was evaluated by artificially creating post-operative data with a known ground truth deformation. The artificial post-operative data was obtained by applying the deformation field from one patient on the pre-operative data of another patient, which was repeated for three patients. The mean error that was found with this method ranged from 1 to 2 mm, while the standard deviation was about 1 mm.

Original languageEnglish
Title of host publicationClinical Image-Based Procedures. Translational Research in Medical Imaging
Subtitle of host publication4th International Workshop, CLIP 2015, Held in Conjunction with MICCAI 2015, Munich, Germany, October 5, 2015. Revised Selected Papers
Place of PublicationDordrecht
Number of pages9
ISBN (Electronic)978-3-319-31808-0
ISBN (Print)9783319318073
Publication statusPublished - 2016
Event4th MICCAI Workshop on Clinical Image-Based Procedures (CLIP 2015), October 5, 2015, Munich, Germany - Munich, Germany
Duration: 5 Oct 20155 Oct 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN (Print)03029743
ISSN (Electronic)16113349


Workshop4th MICCAI Workshop on Clinical Image-Based Procedures (CLIP 2015), October 5, 2015, Munich, Germany
Abbreviated titleCLIP 2015
OtherWorkshop held in conjunction with the 18th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2015)


  • Brain shift
  • Cone-beam CT
  • Craniotomy
  • Elastic registration
  • Open brain surgery


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