Access to cyclic: Gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones

Chérif Adouama; Robert Keyrouz; Guillaume Pilet; Cyrille Monnereau; David Gueyrard; Timothy Noël; Maurice Médebielle

doi:10.1039/c7cc02979a

Access to cyclic: Gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones

Chérif Adouama, Robert Keyrouz, Guillaume Pilet, Cyrille Monnereau, David Gueyrard, Timothy Noël, Maurice Médebielle

Micro Flow Chemistry and Synthetic Methodology

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

A variety of unprecedented scaffolds containing a difluoroacyl moiety were obtained in moderate to good yields, with excellent diastereoselectivity, via electrochemical or photochemical activation of difluoroacyl heteroaryles with a series of olefinic substrates.

Original language	English
Pages (from-to)	5653-5656
Number of pages	4
Journal	Chemical Communications, ChemComm
Volume	53
Issue number	41
DOIs	https://doi.org/10.1039/c7cc02979a
Publication status	Published - 18 May 2017

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10.1039/c7cc02979a

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Access to cyclic: Gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones. / Adouama, Chérif; Keyrouz, Robert; Pilet, Guillaume et al.
In: Chemical Communications, ChemComm, Vol. 53, No. 41, 18.05.2017, p. 5653-5656.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Access to cyclic

T2 - Gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones

AU - Adouama, Chérif

AU - Keyrouz, Robert

AU - Pilet, Guillaume

AU - Monnereau, Cyrille

AU - Gueyrard, David

AU - Noël, Timothy

AU - Médebielle, Maurice

PY - 2017/5/18

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AB - A variety of unprecedented scaffolds containing a difluoroacyl moiety were obtained in moderate to good yields, with excellent diastereoselectivity, via electrochemical or photochemical activation of difluoroacyl heteroaryles with a series of olefinic substrates.

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DO - 10.1039/c7cc02979a

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SN - 1359-7345

VL - 53

SP - 5653

EP - 5656

JO - Chemical Communications, ChemComm

JF - Chemical Communications, ChemComm

IS - 41

ER -

Access to cyclic: Gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones

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