Accelerating visible-light photoredox catalysis in continuous-flow reactors

N.J.W. Straathof, T. Noel

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

5 Citations (Scopus)

Abstract

This chapter gives an overview of the most important examples of visible-light photoredox catalysis in continuous-flow reactors based on the heterogeneity of the reaction mixture (homogeneous, gas-liquid, and solid-liquid). Photocatalysis in a homogeneous single phase can be straightforwardly converted to a continuous-flow protocol. In a continuous-flow system, the mixing efficiency is well controlled by the large and well-defined surface-to-volume ratios and the reaction times are defined by the flow rates. The efficient generation of reactive radical species in a gas-liquid continuous-flow system was demonstrated by Noel et al. for the trifluoromethylation of five-membered heterocycles. For gas-liquid reactions, it is important to maximize the interfacial area to avoid mass transfer limitations. Immobilization of photocatalysts in continuous-flow reactors provides a number of advantages with regard to catalyst recuperation and reuse. Transferring the chemistry to continuous flow resulted in a substantial acceleration of photocatalytic oxidation protocol.

Original languageEnglish
Title of host publicationVisible light photocatalysis in organic chemistry
EditorsCorey Stephenson, Tehshik Yoon, David W.C. MacMillan
Place of PublicationWeinheim
PublisherWiley-VCH Verlag
Chapter13
Pages389-413
Number of pages25
ISBN (Electronic)978-3-527-67414-5
ISBN (Print)978-3-527-33560-2
DOIs
Publication statusPublished - 13 Oct 2017

Keywords

  • Continuous-flow reactors
  • Gas-liquid photocatalysis
  • Heterogeneous photocatalysis
  • Homogeneous photocatalysis
  • Photocatalytic oxidation
  • Single phase flow
  • Visible-light photoredox catalysis

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