A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model

Mario Hevesi, João F Crispim, Carlo A. Paggi, Amel Dudakovic, Wouter van Genechten, Timothy Hewett, Sanjeev Kakar, Aaron J. Krych, Andre J van Wijnen, Daniel Saris (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalTissue Engineering. Part C: Methods
Volume25
Issue number4
DOIs
Publication statusPublished - 19 Mar 2019

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Keywords

  • animal models
  • anterior cruciate ligament
  • reconstruction

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