A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model

Mario Hevesi, João F Crispim, Carlo A. Paggi, Amel Dudakovic, Wouter van Genechten, Timothy Hewett, Sanjeev Kakar, Aaron J. Krych, Andre J van Wijnen, Daniel Saris (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Anterior cruciate ligament (ACL) injuries are frequent, as over 200,000 injuries occur in the United States alone each year. Due to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. The following manuscript provides a clear operative description and associated illustrations for a validated, Institutional Animal Care and Use Committee and veterinarian approved, and facile model of ACLR in order to serve researchers investigating ACLR.

LanguageEnglish
Pages191-196
Number of pages6
JournalTissue Engineering Part C: Methods
Volume25
Issue number4
DOIs
StatePublished - 19 Mar 2019

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Anterior Cruciate Ligament Reconstruction
Ligaments
Anterior Cruciate Ligament
Rabbits
Animal Care Committees
Manuscripts
Veterinarians
Activities of Daily Living
Cartilage
Sports
Orthopedics
Animals
Animal Models
Research Personnel
Reconstruction (structural)
Wounds and Injuries
Research
Anterior Cruciate Ligament Injuries
Repair
Recovery

Cite this

Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., van Genechten, W., Hewett, T., ... Saris, D. (2019). A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model. Tissue Engineering Part C: Methods, 25(4), 191-196. DOI: 10.1089/ten.TEC.2018.0357
Hevesi, Mario ; Crispim, João F ; Paggi, Carlo A. ; Dudakovic, Amel ; van Genechten, Wouter ; Hewett, Timothy ; Kakar, Sanjeev ; Krych, Aaron J. ; van Wijnen, Andre J ; Saris, Daniel. / A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model. In: Tissue Engineering Part C: Methods. 2019 ; Vol. 25, No. 4. pp. 191-196
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title = "A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model",
abstract = "Anterior cruciate ligament (ACL) injuries are frequent, as over 200,000 injuries occur in the United States alone each year. Due to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. The following manuscript provides a clear operative description and associated illustrations for a validated, Institutional Animal Care and Use Committee and veterinarian approved, and facile model of ACLR in order to serve researchers investigating ACLR.",
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Hevesi, M, Crispim, JF, Paggi, CA, Dudakovic, A, van Genechten, W, Hewett, T, Kakar, S, Krych, AJ, van Wijnen, AJ & Saris, D 2019, 'A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model' Tissue Engineering Part C: Methods, vol. 25, no. 4, pp. 191-196. DOI: 10.1089/ten.TEC.2018.0357

A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model. / Hevesi, Mario; Crispim, João F; Paggi, Carlo A.; Dudakovic, Amel; van Genechten, Wouter; Hewett, Timothy; Kakar, Sanjeev; Krych, Aaron J.; van Wijnen, Andre J; Saris, Daniel (Corresponding author).

In: Tissue Engineering Part C: Methods, Vol. 25, No. 4, 19.03.2019, p. 191-196.

Research output: Contribution to journalArticleAcademicpeer-review

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Hevesi M, Crispim JF, Paggi CA, Dudakovic A, van Genechten W, Hewett T et al. A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model. Tissue Engineering Part C: Methods. 2019 Mar 19;25(4):191-196. Available from, DOI: 10.1089/ten.TEC.2018.0357