A supramolecular system for the electrochemically controlled release of cells

Qi An, Jenny Brinkmann, Jurriaan Huskens, Sven Krabbenborg, Jan De Boer, Pascal Jonkheijm

Research output: Contribution to journalArticleAcademicpeer-review

93 Citations (Scopus)

Abstract

Please release me: Electrochemically activated cell release is achieved using a redox-active supramolecular complex (see picture). Host molecule CB[8] (green) links surface-bound viologen (purple) with solution-exposed RGD peptides (red). Electrochemical reduction dissociates the complex, releases the peptides, and thus releases the cells from the substrates. This supramolecular strategy is also applicable to microelectrodes.

Original languageEnglish
Pages (from-to)12233-12237
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number49
DOIs
Publication statusPublished - 3 Dec 2012
Externally publishedYes

Keywords

  • cell detachment
  • host-guest systems
  • stimuli responsive
  • supramolecular chemistry

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