A simulation model to study maternal hyperoxygenation during labor

L. Bullens, M.B. Hout, van der, P.J. Runnard Heimel, van, S.G. Oei

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Abstract

To investigate the effect of maternal hyperoxygenation on fetal oxygenation and fetal heart rate decelerations during labor, using a simulation model. Design Use of a mathematical model that simulates feto–maternal hemodynamics and oxygenation, designed in Matlab R2012a. Setting Clinical and engineering departments in the Netherlands. Methods We simulated variable and late fetal heart rate decelerations, caused by uterine contractions with a different contraction interval. We continuously recorded oxygen pressure in different feto–placental compartments and fetal heart rate, during maternal normoxia and during hyperoxygenation with 100% oxygen. Main outcome measures Changes in oxygen pressure in the intervillous space, umbilical vein and arteries, fetal cerebral and microcirculation as well as fetal heart rate deceleration depth and duration. Results Maternal hyperoxygenation leads to an increase in fetal oxygenation: in the presence of variable decelerations, oxygen pressure in the intervillous space increased 9–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. In addition, fetal heart rate deceleration depth decreased from 45 to 20 beats per minute. In the presence of late decelerations, oxygen pressure in the intervillous space increased 7–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. The fetus benefited more from maternal hyperoxygenation when contraction intervals were longer. Conclusions According to the simulation model, maternal hyperoxygenation leads to an increase in fetal oxygenation, especially in the presence of variable decelerations. In addition, in the presence of variable decelerations, maternal hyperoxygenation leads to amelioration of the fetal heart rate pattern.
Original languageEnglish
Pages (from-to)1268-1275
Number of pages8
JournalActa Obstetricia et Gynecologica Scandinavica
Volume93
Issue number12
DOIs
Publication statusPublished - 2014

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Deceleration
Fetal Heart Rate
Mothers
Oxygen
Cerebrovascular Circulation
Pressure
Uterine Contraction
Umbilical Veins
Umbilical Arteries
Microcirculation
Netherlands
Fetus
Theoretical Models
Hemodynamics

Cite this

@article{93805652cccc44229bf0c566c1ca4a06,
title = "A simulation model to study maternal hyperoxygenation during labor",
abstract = "To investigate the effect of maternal hyperoxygenation on fetal oxygenation and fetal heart rate decelerations during labor, using a simulation model. Design Use of a mathematical model that simulates feto–maternal hemodynamics and oxygenation, designed in Matlab R2012a. Setting Clinical and engineering departments in the Netherlands. Methods We simulated variable and late fetal heart rate decelerations, caused by uterine contractions with a different contraction interval. We continuously recorded oxygen pressure in different feto–placental compartments and fetal heart rate, during maternal normoxia and during hyperoxygenation with 100{\%} oxygen. Main outcome measures Changes in oxygen pressure in the intervillous space, umbilical vein and arteries, fetal cerebral and microcirculation as well as fetal heart rate deceleration depth and duration. Results Maternal hyperoxygenation leads to an increase in fetal oxygenation: in the presence of variable decelerations, oxygen pressure in the intervillous space increased 9–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. In addition, fetal heart rate deceleration depth decreased from 45 to 20 beats per minute. In the presence of late decelerations, oxygen pressure in the intervillous space increased 7–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. The fetus benefited more from maternal hyperoxygenation when contraction intervals were longer. Conclusions According to the simulation model, maternal hyperoxygenation leads to an increase in fetal oxygenation, especially in the presence of variable decelerations. In addition, in the presence of variable decelerations, maternal hyperoxygenation leads to amelioration of the fetal heart rate pattern.",
author = "L. Bullens and {Hout, van der}, M.B. and {Runnard Heimel, van}, P.J. and S.G. Oei",
year = "2014",
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A simulation model to study maternal hyperoxygenation during labor. / Bullens, L.; Hout, van der, M.B.; Runnard Heimel, van, P.J.; Oei, S.G.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 93, No. 12, 2014, p. 1268-1275.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A simulation model to study maternal hyperoxygenation during labor

AU - Bullens, L.

AU - Hout, van der, M.B.

AU - Runnard Heimel, van, P.J.

AU - Oei, S.G.

PY - 2014

Y1 - 2014

N2 - To investigate the effect of maternal hyperoxygenation on fetal oxygenation and fetal heart rate decelerations during labor, using a simulation model. Design Use of a mathematical model that simulates feto–maternal hemodynamics and oxygenation, designed in Matlab R2012a. Setting Clinical and engineering departments in the Netherlands. Methods We simulated variable and late fetal heart rate decelerations, caused by uterine contractions with a different contraction interval. We continuously recorded oxygen pressure in different feto–placental compartments and fetal heart rate, during maternal normoxia and during hyperoxygenation with 100% oxygen. Main outcome measures Changes in oxygen pressure in the intervillous space, umbilical vein and arteries, fetal cerebral and microcirculation as well as fetal heart rate deceleration depth and duration. Results Maternal hyperoxygenation leads to an increase in fetal oxygenation: in the presence of variable decelerations, oxygen pressure in the intervillous space increased 9–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. In addition, fetal heart rate deceleration depth decreased from 45 to 20 beats per minute. In the presence of late decelerations, oxygen pressure in the intervillous space increased 7–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. The fetus benefited more from maternal hyperoxygenation when contraction intervals were longer. Conclusions According to the simulation model, maternal hyperoxygenation leads to an increase in fetal oxygenation, especially in the presence of variable decelerations. In addition, in the presence of variable decelerations, maternal hyperoxygenation leads to amelioration of the fetal heart rate pattern.

AB - To investigate the effect of maternal hyperoxygenation on fetal oxygenation and fetal heart rate decelerations during labor, using a simulation model. Design Use of a mathematical model that simulates feto–maternal hemodynamics and oxygenation, designed in Matlab R2012a. Setting Clinical and engineering departments in the Netherlands. Methods We simulated variable and late fetal heart rate decelerations, caused by uterine contractions with a different contraction interval. We continuously recorded oxygen pressure in different feto–placental compartments and fetal heart rate, during maternal normoxia and during hyperoxygenation with 100% oxygen. Main outcome measures Changes in oxygen pressure in the intervillous space, umbilical vein and arteries, fetal cerebral and microcirculation as well as fetal heart rate deceleration depth and duration. Results Maternal hyperoxygenation leads to an increase in fetal oxygenation: in the presence of variable decelerations, oxygen pressure in the intervillous space increased 9–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. In addition, fetal heart rate deceleration depth decreased from 45 to 20 beats per minute. In the presence of late decelerations, oxygen pressure in the intervillous space increased 7–10 mmHg and in the cerebral circulation 1–2 mmHg, depending on the contraction interval. The fetus benefited more from maternal hyperoxygenation when contraction intervals were longer. Conclusions According to the simulation model, maternal hyperoxygenation leads to an increase in fetal oxygenation, especially in the presence of variable decelerations. In addition, in the presence of variable decelerations, maternal hyperoxygenation leads to amelioration of the fetal heart rate pattern.

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JO - Acta Obstetricia et Gynecologica Scandinavica

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