Abstract
We investigate a fast and sensitive optomagnetic bionanotechnology for biomarker detection. Antibody-coated superparamagnetic particles capture biomarker molecules and form clusters with a biomarker molecule sandwiched between two particles. These particle clusters can be analyzed using a rotating magnetic field which induces an oscillating light scattering cross-section, resolving sub-picomolar biomarker concentrations [Ranzoni et al, Nanoletters 2011; ACS Nano 2012].
In this paper we report a method to quantify the particle-particle distance with nanometer resolution. Simulations of the light scattering by rotating clusters show that the high-frequency components hold detailed information about the geometry of the particle clusters, including a strong dependence on the inter-particle distance. We will report the simulation results and experimental data of model cluster assays.
| Original language | English |
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| Publication status | Published - 2013 |
| Event | conference; Dutch meeting on molecular and cellular biophysics, 2013; 2013-09-30; 2013-10-01 - Duration: 30 Sept 2013 → 1 Oct 2013 |
Conference
| Conference | conference; Dutch meeting on molecular and cellular biophysics, 2013; 2013-09-30; 2013-10-01 |
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| Period | 30/09/13 → 1/10/13 |
| Other | Dutch meeting on molecular and cellular biophysics, 2013 |