A roadmap for poly(ethylene oxide)-block-poly-ε-caprolactone self-assembly in water : prediction, synthesis, and characterization and characterization

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Abstract

Numerical self-consistent field (SCF) lattice computations allow a priori determination of the equilibrium morphology and size of supramolecular structures originating from the self-assembly of neutral block copolymers in selective solvents. The self-assembly behavior of poly(ethylene oxide)-block-poly-ε-caprolactone (PEO-PCL) block copolymers in water was studied as a function of the block composition, resulting in equilibrium structure and size diagrams. Guided by the theoretical SCF predictions, PEO-PCL block copolymers of various compositions have been synthesized and assembled in water. The size and morphology of the resulting structures have been characterized by small-angle X-ray scattering, cryogenic transmission electron microscopy, and multiangle dynamic light scattering. The experimental results are consistent with the SCF computations. These findings show that SCF is applicable to build up roadmaps for amphiphilic polymers in solution, where control over size and shape are required, which is relevant, for instance, when designing spherical micelles for drug delivery syst
LanguageEnglish
Pages330-339
Number of pages10
JournalJournal of Polymer Science, Part B: Polymer Physics
Volume56
Issue number4
DOIs
StatePublished - 15 Feb 2018

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ethylene oxide
Polyethylene oxides
Self assembly
Block copolymers
self consistent fields
self assembly
block copolymers
Water
synthesis
predictions
water
Micelles
Dynamic light scattering
X ray scattering
Chemical analysis
Drug delivery
Cryogenics
Polymers
Transmission electron microscopy
cryogenics

Cite this

@article{94ab2fd94b75466b9e1d527d40090744,
title = "A roadmap for poly(ethylene oxide)-block-poly-ε-caprolactone self-assembly in water : prediction, synthesis, and characterization and characterization",
abstract = "Numerical self-consistent field (SCF) lattice computations allow a priori determination of the equilibrium morphology and size of supramolecular structures originating from the self-assembly of neutral block copolymers in selective solvents. The self-assembly behavior of poly(ethylene oxide)-block-poly-ε-caprolactone (PEO-PCL) block copolymers in water was studied as a function of the block composition, resulting in equilibrium structure and size diagrams. Guided by the theoretical SCF predictions, PEO-PCL block copolymers of various compositions have been synthesized and assembled in water. The size and morphology of the resulting structures have been characterized by small-angle X-ray scattering, cryogenic transmission electron microscopy, and multiangle dynamic light scattering. The experimental results are consistent with the SCF computations. These findings show that SCF is applicable to build up roadmaps for amphiphilic polymers in solution, where control over size and shape are required, which is relevant, for instance, when designing spherical micelles for drug delivery syst",
author = "A. Ianiro and J.P. Patterson and {Gonzalez Garcia}, A. and {van Rijt}, M.M.J. and M.M.R.M. Hendrix and N.A.J.M. Sommerdijk and I.K. Voets and {de Carvalho Esteves}, A.C. and R. Tuinier",
year = "2018",
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journal = "Journal of Polymer Science, Part B: Polymer Physics",
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TY - JOUR

T1 - A roadmap for poly(ethylene oxide)-block-poly-ε-caprolactone self-assembly in water : prediction, synthesis, and characterization and characterization

AU - Ianiro,A.

AU - Patterson,J.P.

AU - Gonzalez Garcia,A.

AU - van Rijt,M.M.J.

AU - Hendrix,M.M.R.M.

AU - Sommerdijk,N.A.J.M.

AU - Voets,I.K.

AU - de Carvalho Esteves,A.C.

AU - Tuinier,R.

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Numerical self-consistent field (SCF) lattice computations allow a priori determination of the equilibrium morphology and size of supramolecular structures originating from the self-assembly of neutral block copolymers in selective solvents. The self-assembly behavior of poly(ethylene oxide)-block-poly-ε-caprolactone (PEO-PCL) block copolymers in water was studied as a function of the block composition, resulting in equilibrium structure and size diagrams. Guided by the theoretical SCF predictions, PEO-PCL block copolymers of various compositions have been synthesized and assembled in water. The size and morphology of the resulting structures have been characterized by small-angle X-ray scattering, cryogenic transmission electron microscopy, and multiangle dynamic light scattering. The experimental results are consistent with the SCF computations. These findings show that SCF is applicable to build up roadmaps for amphiphilic polymers in solution, where control over size and shape are required, which is relevant, for instance, when designing spherical micelles for drug delivery syst

AB - Numerical self-consistent field (SCF) lattice computations allow a priori determination of the equilibrium morphology and size of supramolecular structures originating from the self-assembly of neutral block copolymers in selective solvents. The self-assembly behavior of poly(ethylene oxide)-block-poly-ε-caprolactone (PEO-PCL) block copolymers in water was studied as a function of the block composition, resulting in equilibrium structure and size diagrams. Guided by the theoretical SCF predictions, PEO-PCL block copolymers of various compositions have been synthesized and assembled in water. The size and morphology of the resulting structures have been characterized by small-angle X-ray scattering, cryogenic transmission electron microscopy, and multiangle dynamic light scattering. The experimental results are consistent with the SCF computations. These findings show that SCF is applicable to build up roadmaps for amphiphilic polymers in solution, where control over size and shape are required, which is relevant, for instance, when designing spherical micelles for drug delivery syst

U2 - 10.1002/polb.24545

DO - 10.1002/polb.24545

M3 - Article

VL - 56

SP - 330

EP - 339

JO - Journal of Polymer Science, Part B: Polymer Physics

T2 - Journal of Polymer Science, Part B: Polymer Physics

JF - Journal of Polymer Science, Part B: Polymer Physics

SN - 0887-6266

IS - 4

ER -