A reduced SNARE model for membrane fusion

H. Robson Marsden, N.A. Elbers, P.H.H. Bomans, N.A.J.M. Sommerdijk, A. Kros

Research output: Contribution to journalArticleAcademicpeer-review

103 Citations (Scopus)
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Abstract

A minimal model system was developed to mimic the SNARE-protein-mediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events.
Original languageEnglish
Pages (from-to)2330-2333
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number13
DOIs
Publication statusPublished - 2009

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