A polymersome nanoreactor with controllable permeability induced by stimuli-responsive block copolymers

Kyoung Taek Kim; J.J.L.M. Cornelissen; R.J.M. Nolte; J.C.M. van Hest

doi:10.1002/adma.200900300

A polymersome nanoreactor with controllable permeability induced by stimuli-responsive block copolymers

Kyoung Taek Kim, J.J.L.M. Cornelissen, R.J.M. Nolte, J.C.M. van Hest

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Abstract

A simple method to generate membrane permeability of polymersomes consisting of a conventional amphiphilic block copolymer, polyethylene glycol-block-polystyrene (PEG-b-PS), was devised. The three block copolymers are self-assembled into spherical objects, and these objects observed by transmission electron microscopy (TEM) show an average diameter in the range of 200-400 nm. The polymersomes constitute of PEG-b-PSBA containing boronic acid moieties as stimulus-responsive centers, and exhibit both pH and sugar-responsive disassembly into molecularly dissolved block copolymers. It is also shown that when mixed in ratios of 30 wt% and lower, the two block copolymers coexist as a mixture in the membrane of the polymersome without experiencing complete phase separation. After the disassembly of the polymersome at pH 12.6 for 1h, the polymersome solution show fluorescence only in the later elution fractions.

Original language	English
Pages (from-to)	2787-2791
Number of pages	5
Journal	Advanced Materials
Volume	21
Issue number	27
DOIs	https://doi.org/10.1002/adma.200900300
Publication status	Published - 20 Jul 2009

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abstract = "A simple method to generate membrane permeability of polymersomes consisting of a conventional amphiphilic block copolymer, polyethylene glycol-block-polystyrene (PEG-b-PS), was devised. The three block copolymers are self-assembled into spherical objects, and these objects observed by transmission electron microscopy (TEM) show an average diameter in the range of 200-400 nm. The polymersomes constitute of PEG-b-PSBA containing boronic acid moieties as stimulus-responsive centers, and exhibit both pH and sugar-responsive disassembly into molecularly dissolved block copolymers. It is also shown that when mixed in ratios of 30 wt% and lower, the two block copolymers coexist as a mixture in the membrane of the polymersome without experiencing complete phase separation. After the disassembly of the polymersome at pH 12.6 for 1h, the polymersome solution show fluorescence only in the later elution fractions.",

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AU - Cornelissen, J.J.L.M.

AU - Nolte, R.J.M.

AU - van Hest, J.C.M.

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AB - A simple method to generate membrane permeability of polymersomes consisting of a conventional amphiphilic block copolymer, polyethylene glycol-block-polystyrene (PEG-b-PS), was devised. The three block copolymers are self-assembled into spherical objects, and these objects observed by transmission electron microscopy (TEM) show an average diameter in the range of 200-400 nm. The polymersomes constitute of PEG-b-PSBA containing boronic acid moieties as stimulus-responsive centers, and exhibit both pH and sugar-responsive disassembly into molecularly dissolved block copolymers. It is also shown that when mixed in ratios of 30 wt% and lower, the two block copolymers coexist as a mixture in the membrane of the polymersome without experiencing complete phase separation. After the disassembly of the polymersome at pH 12.6 for 1h, the polymersome solution show fluorescence only in the later elution fractions.

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A polymersome nanoreactor with controllable permeability induced by stimuli-responsive block copolymers

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