A phase-cycled temperature-sensitive fast spin echo sequence with conductivity bias correction for monitoring of mild RF hyperthermia with PRFS

Mingming Wu (Corresponding author), Hendrik T. Mulder, Yuval Zur, Silke Lechner-Greite, Marion I. Menzel, Margarethus M. Paulides, Gerard C. van Rhoon, Axel Haase

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: Mild hyperthermia (HT) treatments are generally monitored by phase-referenced proton resonance frequency shift calculations. A novel phase and thus temperature-sensitive fast spin echo (TFSE) sequence is introduced and compared to the double echo gradient echo (DEGRE) sequence.

THEORY AND METHODS: For a proton resonance frequency shift (PRFS)-sensitive TFSE sequence, a phase cycling method is applied to separate even from odd echoes. This method compensates for conductivity change-induced bias in temperature mapping as does the DEGRE sequence. Both sequences were alternately applied during a phantom heating experiment using the clinical setup for deep radio frequency HT (RF-HT). The B0 drift-corrected temperature values in a region of interest around temperature probes are compared to the temperature probe data and further evaluated in Bland-Altman plots. The stability of both methods was also tested within the thighs of three volunteers at a constant temperature using the subcutaneous fat layer for B0-drift correction.

RESULTS: During the phantom heating experiment, on average TFSE temperature maps achieved double temperature-to-noise ratio (TNR) efficiency in comparison with DEGRE temperature maps. In-vivo images of the thighs exhibit stable temperature readings of ± 1 °C over 25 min of scanning in three volunteers for both methods. On average, the TNR efficiency improved by around 25% for in vivo data.

CONCLUSION: A novel TFSE method has been adapted to monitor temperature during mild HT.

LanguageEnglish
Pages369-380
Number of pages12
JournalMagnetic Resonance Materials in Physics, Biology and Medicine (MAGMA)
Volume32
Issue number3
DOIs
StatePublished - Jun 2019

Fingerprint

Protons
Fever
Temperature
Thigh
Heating
Noise
Volunteers
Subcutaneous Fat
Radio
Reading

Keywords

  • Conductivity
  • Double echo gradient echo
  • Fast spin echo
  • Hyperthermia
  • Intervention
  • MR thermometry
  • Proton resonance frequency shift

Cite this

Wu, Mingming ; Mulder, Hendrik T. ; Zur, Yuval ; Lechner-Greite, Silke ; Menzel, Marion I. ; Paulides, Margarethus M. ; van Rhoon, Gerard C. ; Haase, Axel. / A phase-cycled temperature-sensitive fast spin echo sequence with conductivity bias correction for monitoring of mild RF hyperthermia with PRFS. In: Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA). 2019 ; Vol. 32, No. 3. pp. 369-380
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abstract = "OBJECTIVE: Mild hyperthermia (HT) treatments are generally monitored by phase-referenced proton resonance frequency shift calculations. A novel phase and thus temperature-sensitive fast spin echo (TFSE) sequence is introduced and compared to the double echo gradient echo (DEGRE) sequence.THEORY AND METHODS: For a proton resonance frequency shift (PRFS)-sensitive TFSE sequence, a phase cycling method is applied to separate even from odd echoes. This method compensates for conductivity change-induced bias in temperature mapping as does the DEGRE sequence. Both sequences were alternately applied during a phantom heating experiment using the clinical setup for deep radio frequency HT (RF-HT). The B0 drift-corrected temperature values in a region of interest around temperature probes are compared to the temperature probe data and further evaluated in Bland-Altman plots. The stability of both methods was also tested within the thighs of three volunteers at a constant temperature using the subcutaneous fat layer for B0-drift correction.RESULTS: During the phantom heating experiment, on average TFSE temperature maps achieved double temperature-to-noise ratio (TNR) efficiency in comparison with DEGRE temperature maps. In-vivo images of the thighs exhibit stable temperature readings of ± 1 °C over 25 min of scanning in three volunteers for both methods. On average, the TNR efficiency improved by around 25{\%} for in vivo data.CONCLUSION: A novel TFSE method has been adapted to monitor temperature during mild HT.",
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A phase-cycled temperature-sensitive fast spin echo sequence with conductivity bias correction for monitoring of mild RF hyperthermia with PRFS. / Wu, Mingming (Corresponding author); Mulder, Hendrik T.; Zur, Yuval; Lechner-Greite, Silke; Menzel, Marion I.; Paulides, Margarethus M.; van Rhoon, Gerard C.; Haase, Axel.

In: Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA), Vol. 32, No. 3, 06.2019, p. 369-380.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Wu,Mingming

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AU - Zur,Yuval

AU - Lechner-Greite,Silke

AU - Menzel,Marion I.

AU - Paulides,Margarethus M.

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AU - Haase,Axel

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