A paraplegic patient with fever and leucocytosis: not always what it seems

Ashley J.R. de Bie (Corresponding author), Simon Körver, Erik Kersten, Jérôme M.H. Kisters, Henricus J.E.J. Vrijhof, Jeroen Willems

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A 54-year-old obese woman with a history of spina bifida was admitted to the hospital with malaise and fever accompanied by leucocytosis, thrombocytosis, and hypercalcaemia. As treatment for neurogenic bladder dysfunction she had a suprapubic catheter. Diagnostic workup for osteomyelitis revealed an unknown mass originating from the urinary bladder on MRI of the pelvis. Further diagnostic analyses showed that the mass was a squamous-cell carcinoma (SCC) with laboratory abnormalities as paraneoplastic phenomena mediated by PTH-related peptide and cytokines released by the SCC. Despite radiotherapy the patient died within two months after initial diagnosis. Squamous-cell carcinoma of the bladder is rare in western countries. In unresectable or metastatic disease survival rates are low due to low responsiveness to standard chemotherapy. Concurrent chemoradiotherapy might be an alternative in unresectable or locally advanced disease; however, evidence to support this is lacking. The poor survival in these patients raises the question of whether high-risk groups for SCC of the bladder, like paraplegic patients or patient with neurogenic bladder dysfunction, should receive screening even though the ideal starting point and frequency are still unknown.

LanguageEnglish
Pages71-74
Number of pages4
JournalOncology in Clinical Practice
Volume15
Issue number1
DOIs
StatePublished - 1 Jan 2019

Fingerprint

Leukocytosis
Squamous Cell Carcinoma
Fever
Neurogenic Urinary Bladder
Urinary Bladder
Parathyroid Hormone-Related Protein
Thrombocytosis
Spinal Dysraphism
Hypercalcemia
Chemoradiotherapy
Osteomyelitis
Pelvis
Radiotherapy
Catheters
Survival Rate
Cytokines
Drug Therapy
Survival
Therapeutics

Keywords

  • Neoplastic phenomena
  • Squamous-cell carcinoma suprapubic tract
  • Suprapubic catheter

Cite this

de Bie, A. J. R., Körver, S., Kersten, E., Kisters, J. M. H., Vrijhof, H. J. E. J., & Willems, J. (2019). A paraplegic patient with fever and leucocytosis: not always what it seems. Oncology in Clinical Practice, 15(1), 71-74. DOI: 10.5603/OCP.2019.0005
de Bie, Ashley J.R. ; Körver, Simon ; Kersten, Erik ; Kisters, Jérôme M.H. ; Vrijhof, Henricus J.E.J. ; Willems, Jeroen. / A paraplegic patient with fever and leucocytosis : not always what it seems. In: Oncology in Clinical Practice. 2019 ; Vol. 15, No. 1. pp. 71-74
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de Bie, AJR, Körver, S, Kersten, E, Kisters, JMH, Vrijhof, HJEJ & Willems, J 2019, 'A paraplegic patient with fever and leucocytosis: not always what it seems' Oncology in Clinical Practice, vol. 15, no. 1, pp. 71-74. DOI: 10.5603/OCP.2019.0005

A paraplegic patient with fever and leucocytosis : not always what it seems. / de Bie, Ashley J.R. (Corresponding author); Körver, Simon; Kersten, Erik; Kisters, Jérôme M.H.; Vrijhof, Henricus J.E.J.; Willems, Jeroen.

In: Oncology in Clinical Practice, Vol. 15, No. 1, 01.01.2019, p. 71-74.

Research output: Contribution to journalArticleAcademicpeer-review

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de Bie AJR, Körver S, Kersten E, Kisters JMH, Vrijhof HJEJ, Willems J. A paraplegic patient with fever and leucocytosis: not always what it seems. Oncology in Clinical Practice. 2019 Jan 1;15(1):71-74. Available from, DOI: 10.5603/OCP.2019.0005