A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

F. Helderman; I.J. Manoch; M. Breeuwer; U. Kose; O. Schouten; M.R.H.M. Sambeek, van; D. Poldermans; T.M. Pattynama; W. Wisselink; A.F.W. Steen, van der; R. Krams

doi:10.1007/s11517-008-0358-3

A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

F. Helderman, I.J. Manoch, M. Breeuwer, U. Kose, O. Schouten, M.R.H.M. Sambeek, van, D. Poldermans, T.M. Pattynama, W. Wisselink, A.F.W. Steen, van der, R. Krams

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Abstract

Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.

Original language	English
Pages (from-to)	1121-1127
Number of pages	7
Journal	Medical and Biological Engineering and Computing
Volume	46
Issue number	11
DOIs	https://doi.org/10.1007/s11517-008-0358-3
Publication status	Published - 2008
Externally published	Yes

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Helderman, F., Manoch, I. J., Breeuwer, M., Kose, U., Schouten, O., Sambeek, van, M. R. H. M., Poldermans, D., Pattynama, T. M., Wisselink, W., Steen, van der, A. F. W., & Krams, R. (2008). A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness. Medical and Biological Engineering and Computing, 46(11), 1121-1127. https://doi.org/10.1007/s11517-008-0358-3

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title = "A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness",

abstract = "Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.",

author = "F. Helderman and I.J. Manoch and M. Breeuwer and U. Kose and O. Schouten and {Sambeek, van}, M.R.H.M. and D. Poldermans and T.M. Pattynama and W. Wisselink and {Steen, van der}, A.F.W. and R. Krams",

year = "2008",

doi = "10.1007/s11517-008-0358-3",

language = "English",

volume = "46",

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journal = "Medical and Biological Engineering and Computing",

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Helderman, F, Manoch, IJ, Breeuwer, M, Kose, U, Schouten, O, Sambeek, van, MRHM, Poldermans, D, Pattynama, TM, Wisselink, W, Steen, van der, AFW & Krams, R 2008, 'A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness', Medical and Biological Engineering and Computing, vol. 46, no. 11, pp. 1121-1127. https://doi.org/10.1007/s11517-008-0358-3

TY - JOUR

T1 - A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

AU - Helderman, F.

AU - Manoch, I.J.

AU - Breeuwer, M.

AU - Kose, U.

AU - Schouten, O.

AU - Sambeek, van, M.R.H.M.

AU - Poldermans, D.

AU - Pattynama, T.M.

AU - Wisselink, W.

AU - Steen, van der, A.F.W.

AU - Krams, R.

PY - 2008

Y1 - 2008

N2 - Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.

AB - Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.

U2 - 10.1007/s11517-008-0358-3

DO - 10.1007/s11517-008-0358-3

M3 - Article

C2 - 18521644

SN - 0140-0118

VL - 46

SP - 1121

EP - 1127

JO - Medical and Biological Engineering and Computing

JF - Medical and Biological Engineering and Computing

IS - 11

ER -

A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

Abstract

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